蛋白质精氨酸甲基转移酶1调控DNA损伤修复和细胞凋亡

Arginine methyltransferase 1 regulates DNA damage repair and apoptosis

蛋白质精氨酸甲基转移酶1 (protein arginine methyltransferases 1, PRMT1)是PRMT家族中的重要一员,属于Ⅰ型PRMTs,细胞内超过85%的蛋白质精氨酸的甲基化由其催化。PRMT1通过调节底物的甲基化水平,从而调控蛋白的功能及蛋白参与的细胞活动和生理过程,包括细胞信号转导,DNA损伤修复,转录调控,RNA代谢,蛋白质相互作用等。本文着重讨论PRMT1的结构、底物及其在DNA损伤修复和细胞凋亡中的功能。

Protein arginine methyltransferases 1(PRMT1),a pivotal member of the protein arginine methyltransferase family belongs to typeⅠPRMTs and catalyzes over 85%of all protein arginine methylations.By modulating the methylation levels of substrates,PRMT1 regulates protein functions and many cellular and physiological processes including cell signal transduction,DNA damage repair,transcriptional regulation,RNA metabolism,and protein interactions.This review mainly summarizes the structure and substrates of PRMT1,emphasizing the function of PRMT1 in regulating DNA damage repair and apoptosis.