肺癌循环肿瘤细胞侵袭转移机制的研究进展

Research Advances in the Mechanism of Invasion and Metastasis of Circulating Tumor Cells in Lung Cancer

近年来,随着液体活检技术兴起,循环肿瘤细胞(circulating tumor cell,CTC)在癌症患者的早期诊断、疗效评估及预后评价等方面显示出重要的价值。CTC的产生导致肿瘤发生远处转移及患者的预后不良。因此,阐明CTC的产生、进入循环系统及其免疫逃逸的机制尤为重要。目前,精准诊疗成为提高肺癌患者预后的重要努力方向。针对肺癌CTC有望为肺癌精准诊疗提供有力的理论依据与重要手段。现对上述热点问题的最新研究进展进行综述。

In recent years,with the emergence of liquid biopsies,circulating tumor cells(CTCs)demonstrated significant value in the early diagnosis of patients with cancer,curative effect evaluation and prognosis evaluation.CTCs are the main cause of tumor metastasis,which indicates the poor prognosis of patients.Therefore,it is particularly important to elucidate the mechanism of CTC’s generation,how to entry into circulatory system and immune escape.At present,accurate diagnosis and treatment has become an important direction to improve the prognosis of lung cancer patients.CTC for lung cancer is expected to provide a strong theoretical basis and important methods for accurate diagnosis and treatment of lung cancer.This paper reviews the latest research progress on the above hot issues.