鸢尾素在炎性疾病中的抗炎作用

Anti-inflammatory effects of irisin in inflammatory diseases

目的总结鸢尾素在炎性疾病中的抗炎作用。方法系统检索并阅读近年来国内外关于鸢尾素抗炎作用研究的相关文献并进行综述。结果鸢尾素在体内分布广泛并发挥着诱导白色脂肪细胞褐变、改善能量代谢、提高葡萄糖利用率等生理学作用。在急性肺损伤、炎症性肠病、脓毒性心肌病、急性胰腺炎、非酒精性脂肪性肝病和恶性肿瘤中通过抑制白细胞介素-6、肿瘤坏死因子-α等炎症因子升高,拮抗细胞凋亡和核因子-κB活化、改善组织损伤等机制发挥重要抗炎作用。结论鸢尾素在炎症性肠病、急性肺损伤等炎性疾病中发挥重要抗炎作用,有望作为炎性疾病诊断和预后的生物标志物并成为炎症疾病治疗的新靶点。

Objective To summarize the anti-inflammatory effects of irisin in inflammatory diseases.Method The relevant literatures at home and abroad in recent years were systematically searched and read to review the anti-inflammatory effects of irisin in the inflammatory diseases.Results The irisin was widely distributed in the body and played a physiological role in inducing the browning of white adipocytes,improving energy metabolism and glucose utilization.A grow body of evidences demonstrated that the irisin exerted the anti-inflammatory effects by inhibiting increased pro-inflammatory cytokines and tumor necrosis factor-α,antagonizing apoptosis and activation of nuclear factor-κB,and improving tissue damage in many inflammatory diseases,such as acute lung injury,inflammatory bowel disease,septic cardiomyopathy,acute pancreatitis,nonalcoholic fatty liver disease,and malignant tumors.Conclusions Irisin plays an important anti-inflammatory role in pathogenesis of inflammatory diseases.Irisin is considered as a promising candidate biomarker for diagnosis and prognosis of inflammatory diseases,and a novel target for treatment of inflammatory diseases.