骨化三醇冲击治疗尿毒症甲状旁腺功能亢进效果评价

Evaluation of the Effect of Calcitriol on the Hyperparathyroidism in Uremia

目的 研究分析尿毒症甲状旁腺功能亢进患者实施骨化三醇冲击治疗的应用效果及临床疗效.方法 选取沭阳协和医院2016年1月至2018年12月收治的尿毒症甲状旁腺功能亢进患者38例为研究对象,采用随机数字表法将其分为实验组与对照组,各19例.其中对照组采用骨化三醇常规剂量治疗,频率为2次/d,剂量为0.25μg/次;实验组采用骨化三醇冲击治疗,频率为2次/周,剂量为2μg/次.对比2组患者的临床治疗效果以及2组患者的治疗前后碱性磷酸酯情况、甲状旁腺激素情况.比较2组患者的并发症以及不良发生情况、治疗满意度情况.结果 治疗前2组尿毒症甲状旁腺功能亢进患者的碱性磷酸酯情况、甲状旁腺激素情况比较差异无统计学意义(P>0.05),治疗之后,2组患者的相关数据均有所提升,与治疗前比较差异有统计学意义(P<0.05).实验组的患者的相关数据情况明显优于对照组,组间比较差异有统计学意义(P<0.05).实验组尿毒症甲状旁腺功能亢进疾病临床治疗有效率94.73%,高于对照组的68.42%,组间比较差异有统计学意义(P<0.05).结论 尿毒症甲状旁腺功能亢进患者实施骨化三醇冲击治疗效果优于常规剂量治疗.

Objective To study the application effect and clinical efficacy of calcitriol shock therapy in patients with uremia complicated with hyperparathyroidism.Methods Totally 38 patients with hyperparathyroidism of uremia admitted to shuyang union hospital from January 2016 to December 2018 were selected as the study objects,and randomly divided into experimental group and control group with 19 cases each.The control group was treated with a routine dose of ossified triol,with a frequency of 2 times/d and a dose of 0.25 g/time.The experimental group was treated with ossified triol shock therapy with a frequency of 2 times/w and a dose of 2 g/time.The clinical treatment effect of the two groups of patients and the status of alkaline phosphate ester and parathyroid hormone before and after treatment were compared.Complications,adverse events and treatment satisfaction were compared between the two groups.Results Before the treatment,there was no significant difference in the basic phosphate and parathyroid hormone between the two groups(P>0.05).After the treatment,the relevant data of the two groups were improved,and the difference was statistically significant(P<0.05).The data of the experimental group was significantly better than that of the control group,and the difference between the two groups was statistically significant(P<0.05).The effective rate of clinical treatment of uremic hyperparathyroidism in the experimental group was 94.73%,higher than that in the control group(68.42%).The difference between the two groups was statistically significant(P<0.05).Conclusion The implementation of calcitriol shock in patients with uremia with hyperparathyroidism can be further promoted and applied.