口服声诺维微泡超声增强剂与胃助显剂混合液对胃食管反流病的诊断效能

Oral SonoVue microbubble contrast agent and gastric adjuvant mixture for the diagnosis of gastroesophageal reflux disease

目的探讨口服声诺维微泡超声增强剂与胃助显剂混合液对胃食管反流病(GERD)的诊断效能。方法选取2018年5月~2019年11月经成都市龙泉驿区第一人民医院消化内科确诊的66例GERD患者为研究对象,其中男性31例,女性35例;年龄21~82岁,平均(51.5±14.24)岁。对66例患者分别采用胃助显剂(胃助显剂组)及口服声诺维微泡超声增强剂与胃助显剂混合液(混合液组)的诊断结果进行对比分析。口服声诺维微泡超声增强剂与胃助显剂按2.5∶500配制,分别在常规模式及造影模式下观察胃食管反流声像图的表现特征,频谱多普勒记录反流时间、反流次数及反流速度,比较胃助显剂组及混合液组对GERD的诊断效能,并与胃镜检查结果(胃镜组)进行对比分析。结果混合液组在造影模式下检出53例,阳性率80.30%,未检出13例,阴性率19.70%;胃助显剂组检出42例,阳性率63.64%,未检出24例,阴性率36.36%;胃镜检出21例,阳性率31.82%,未检出45例,阴性率68.18%。混合液组诊断效能明显高于胃助显剂组及胃镜组(P<0.05)。53例胃食管反流患者有11例合并食管裂孔疝。结论口服声诺维微泡超声增强剂与胃助显剂混合液在超声造影模式下诊断GERD优于单一胃助显剂及胃镜,可实时客观显示有无反流声像及反流宽度与反流高度等,能明显提高对GERD的诊断效能,为临床诊断GERD开辟了一种新的无创性检查方法。

Objective To study the diagnostic efficiency of Gastroesophageal Reflux Disease(GRED) with mix liquid of oral ultrasound microbubble SonoVue and gastroenterologic ultrasound developer. Methods The clinical diagnosis of 66 GRED patients were collected from May 2018 to November 2019 in our hospital, including 31 male and 35 female cases, aged from 21 to 82, with an average age of(51.5±14.24). A retrospective analysis of the 66 GRED patients was conducted by comparing the diagnosis results of gastroenterultrasound developer(Stomach Ultrasound Developer Group) with mix liquid of oral ultrasound microbubble SonoVue and Stomach ultrasound developer(Mixture Group). Oral ultrasound microbubble SonoVue and gastroenterultrasound developer were mixed by 2.5∶500. The sonogram features of GRED were observed in convential mode and angiographic mode respectively. The frequency spectrum Doppler was used to record the reflux time, reflux frequency and reflux speed and the diagnostic efficacy of stomach ultrasound Developer Group and Mix Liquid Group were compared. The results were compared with gastroscopy and all 66 cases were collected by detection results of gastroscopy and gastroscope specimen. Results 53 cases were detected by Mixture Group with positive rate 80.3%(53/66), 13 cases were not detected with negative rate 19.7%. 42 cases were detected by stomach ultrasound Developer Group with positive rate 63.64%(42/66), 24 cases were not detected with negative rate 36.36%. 21 cases were detected by gastroscopy with positive rate 31.82%(21/66), 45 cases were not detected with negative rate 68.18%. The diagnostic efficacy of the mixture group was significantly higher than that of the stomach ultrasound developer(P<0.05), as well as the gastroscope group(P<0.05). There were 11 esophageal hiatal hernia cases in 53 GRED patients. Conclusion Oral SonoVue microbubble contrast agent and gastric adjuvant mixture is superior to single gastric adjuvant and gastroscope in the diagnosis of GERD in contrast-enhanced ultrasound mode. It can show whether there is reflux image, reflux width and reflux height in real-time and objectively. It can significantly improve the diagnostic efficiency of GERD and open up a new inspection method for clinical diagnosis of GERD.