丁苯酞注射液对急性脑梗死患者血清MMP-9及IL-35中的表达影响及意义

Effect and Significance of Butylphthalide Injection on Expression of Serum MMP-9 and IL-35 in Patients with Acute Cerebral Infarction

目的观察丁苯酞注射液对急性脑梗死患者神经功能及血清MMP-9及IL-35影响及意义。方法将50例急性脑梗死患者随机分为丁苯酞组和对照组各25例。两组均给予常规抗血小板聚集、抗动脉粥样硬化等治疗,丁苯酞组在此基础上给予丁苯酞注射液100mL静滴,2次/d。于治疗前、治疗后3d、7d和14d检测两组患者NIHSS评分及血清MMP-9及IL-35的水平变化。结果丁苯酞组在治疗后7d和14d,NIHSS评分,血清MMP-9及水平均较对照组明显降低,血清中L-35水平均较对照组明显升高,差异有统计学意义(P<0.05)。结论丁苯酞注射液促进脑梗死患者神经功能恢复,改善患者预后的机制之一可能是通过降低患者血清MMP-9的同时升高IL-35水平来发挥作用。

Objective To observe the effect and significance of butylphthalide injection on nerve function and serum MMP-9 and IL-35 in patients with acute cerebral infarction.Methods 50 patients with acute cerebral infarction were randomly divided into butylphthalide group and the control group(n=25).Both groups were given conventional antiplatelet aggregation,anti-atherosclerosis treatment,and the butylphthalide group was given 100ml(bid)butylphthalide injection on this basis.NIHSS score and serum levels of MMP-9 and IL-35 were measured before and after treatment on day 3,7 and 14.Results NIHSS scores,serum MMP-9 and IL-35 levels in the butylphthalide group were significantly lower than those in the control group at 7d and 14d after treatment,and the differences were statistically significant(P<0.05).Conclusion Butylphthalide injection promotes the recovery of nerve function in patients with cerebral infarction and improve the prognosis of patients,which one of the mechanisms might by reducing the serum MMP-9 and while increasing the level of IL-35.