硫酸镁联合拉贝洛尔治疗早发型重度子痫前期的效果

Effect of Magnesium Sulfate Combined with Labetalol in the Treatment of Early-Onset Severe Preeclampsia

目的研究早发型重度子痫前期患者采用硫酸镁联合拉贝洛尔的治疗效果.方法选取江苏省连云港妇幼保健医院2015年1月至2019年8月收治的70例早发型重度子痫前期患者,采用抽签法分观察组(硫酸镁联合拉贝洛尔)与对照组(硫酸镁),各35例.比较两组血压、24h蛋白尿与妊娠结局.结果两组治疗前血压比较,差异无统计学意义(P>0.05);治疗后,与对照组相比观察组舒张压、收缩压与24h蛋白尿值及不良妊娠发生率均明显降低(P<0.05).结论硫酸镁联合拉贝洛尔治疗早发型重度子痫前期患者能有效控制血压且降低24h蛋白尿指标,改善妊娠结局.

Objective To study the effect of magnesium sulfate combined with labetalol in patients with earlyonset severe preeclampsia.Methods Totally 70 patients with early-onset severe preeclampsia from January 2015 to August 2019 in Lianyungang Maternal and Child Health Hospital of Jiangsu Province were randomly divided into an observation group(magnesium sulphate combined with labetalol)and a control group(magnesium sulphate)by lottery with 35 cases each.The blood pressure,24 h proteinuria and pregnancy outcome were compared between the two groups.Results There was no significant difference in blood pressure before treatment between the two groups(P>0.05).Compared with the control group,the diastolic blood pressure,systolic blood pressure,24 h proteinuria level and incidence of adverse pregnancy were significantly decreased in the observation group after treatment(all P<0.05).Conclusion Magnesium sulfate combined with labetalol in the treatment of patients with early-onset severe preeclampsia can effectively control the blood pressure,reduce 24 h proteinuria level,and improve the pregnancy outcome.