丙种球蛋白联用甲强龙对重症肌无力患者TGFβ-1、IL-6的影响

Effect of Gamma Globulin Combined with Methylprednisolone on TGFβ-1 and IL-6 in Patients with Myasthenia Gravis

目的探究丙种球蛋白联用甲强龙对重症肌无力患者TGFβ-1、IL-6的影响.方法选取威海市立医院2018年3月至2019年8月收治的106例重症肌无力患者,随机分为对照组和观察组,各53例.两组均给予胆碱酯酶抑制剂治疗,对照组给予甲强龙治疗,观察组在对照组基础上给予丙种球蛋白治疗.两组均治疗60d.比较两组临床疗效和不良反应、治疗前后血清指标.结果观察组临床总有效率94.34%(50/53)显著高于对照组的77.36%(41/53)(P<0.05).与治疗前相比,治疗后两组血清TGF-β1明显升高,且观察组高于对照组(P<0.05),血清IL-6及IL-2均显著降低,且观察组低于对照组(P<0.05),两组患者不良反应发生率差异无统计学意义(P>0.05).结论丙种球蛋白联合甲强龙治疗重症肌无力患者可显著提高临床疗效,恢复免疫功能,改善血清指标,安全性较好.

Objective To explore the effect of gamma globulin combined with methylprednisolone on TGFβ-1 and IL-6 in patients with myasthenia gravis.Methods One hundred and six patients with myasthenia gravis admitted to Weihai Municipal Hospital from March 2018 to August 2019 were randomly divided into control group and observation group,53 cases each.Both groups were given cholinesterase inhibitor treatment,the control group was given methylprednisolone treatment,the observation group was given gamma globulin treatment on the basis of the control group.Both groups were treated for 60 days.The clinical efficacy,adverse reactions and serum indexes before and after treatment were compared between the two groups.Results The total clinical effective rate of the observation group was 94.34%(50/53),which was significantly higher than that of the control group 77.36%(41/53)(P<0.05).Compared with that before treatment,the serum TGFβ-1 of the two groups was significantly higher after treatment,and that of the observation group was higher than that of the control group(P<0.05),serum IL-6 and IL-2 decreased significantly,the observation group was lower than the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Gamma globulin combined with methylprednisolone in the treatment of myasthenia gravis patients can significantly improve the clinical efficacy,restore the immune function,improve the serum indicators,with good safety.