不同甲氨蝶呤方案治疗异位妊娠患者对患者肝功能的影响

Analysis of Abnormal Liver Function Caused by Different Methotrexate Regimens in Patients with Ectopic Pregnancy

目的研究分析不同的甲氨蝶呤方案治疗非破裂型异位妊娠对患者肝功能的影响效果.方法选取2017年1月至2019年6月江苏省常州市金坛区第二人民医院收治的异位妊娠患者50例,采用随机数表法随机分为观察组和对照组,各25例,对照组患者单用甲氨蝶呤,观察组采用甲氨蝶呤联合米非司酮进行治疗,比较两组治疗效果.结果两组患者治疗前谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、总蛋白(TP)、总胆红素(TBIL)水平比较差异均无统计学意义(P>0.05).观察组患者用药后ALT、ALP、TP、TBIL水平显著低于对照组,观察组患者肝功能异常发生率显著低于对照组(P<0.05).结论采用甲氨蝶呤联合米非司酮治疗异位妊娠可以在一定程度上预防药物对患者造成的肝功能异常.

Objective To study the effect of different methotrexate regimens on liver function in patients with non rupture ectopic pregnancy.Methods From January 2017 to June 2019,50 patients with ectopic pregnancy were randomly divided into the observation group and the control group,25 cases in each group.The control group was treated with methotrexate alone,and the observation group was treated with methotrexate combined with mifepristone.The therapeutic effect of the two groups were compared.Results There was no significant difference in alanine aminotransferase(ALT),alkaline phosphatase(ALP),total protein(TP),total bilirubin(TBIL)between the two groups before treatment(P>0.05).The levels of alt,ALP,TP and TBIL in the observation group were significantly lower than those in the control group,and the incidence of liver dysfunction in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Methotrexate combined with mifepristone in the treatment of ectopic pregnancy can prevent the liver dysfunction caused by drugs to a certain extent.