超微通道与标准通道经皮肾镜取石术对肾结石患者肾功能及CRP、IL-6水平影响

The Effect of Percutaneous Nephrolithotomy with Ultramicro Channel and Standard Channel on Renal Function and the Levels of CRP and IL-6 in Patients with Renal Calculi

目的探讨超微通道经皮肾镜取石术(SMP)与标准通道经皮肾镜取石术(PCNL)对肾结石患者肾功能及C反应蛋白(CRP)、白介素(IL)-6水平的影响。方法回顾性分析长治市人民医院2018年4月至2019年4月收治的74例肾结石患者的临床诊疗资料,包括37例SMP患者(实验组)和37例PCNL患者(对照组);比较2组手术相关指标、术前术后血清CRP、IL-6、血肌酐、尿素氮水平以及术后并发症发生率。结果2组术后72 h的血清CRP、IL-6、血肌酐及尿素氮水平均较本组术前降低,且实验组降低幅度更明显(P<0.05);实验组的术中出血量少于对照组,住院时间及术后肾造瘘管留置时间短于对照组,且术后并发症发生率低于对照组(P<0.05)。结论SMP可利于减少肾结石患者的术中出血量,缩短其术后肾造瘘管留置时间及住院时间,可以有效抑制炎性反应,减少相关术后并发症发生率,能够促进临床治疗效果的提高,有重要作用。

Objective To investigate the effects of ultramicro channel percutaneous nephrolithotomy(SMP)and standard channel percutaneous nephrolithotomy(PCNL)on renal function,C-reactive protein(CRP)and interleukin-6(IL-6)levels in patients with renal calculi.Methods A retrospective analysis of changzhi city people's hospital between April 2018 and April 2019 were analyzed.the clinical data of 74 patients with renal calculi,including 37 SMP patients(experimental group)and 37 PCNL patients(control group);The operation related indexes,serum CRP,IL-6,serum creatinine,urea nitrogen levels and postoperative complications were compared between the two groups.Results The levels of serum CRP,IL-6,creatinine and urea nitrogen in the two groups at 72 hours after operation were lower than those in the group before operation,and the decrease range in the experimental group was more significant(P<0.05);The amount of bleeding in the experimental group was less than that in the control group,the time of hospitalization and the time of indwelling nephrostomy tube were shorter than that in the control group,and the incidence of postoperative complications was lower than that in the control group(P<0.05).Conclusion SMP can reduce the amount of bleeding during the operation of renal calculi,shorten the retention time and hospitalization time of nephrostomy tube,effectively inhibit the inflammatory reaction,reduce the incidence of related postoperative complications,and promote the improvement of clinical treatment effect.