伊伐布雷定联合美托洛尔对CHF患者血气及LVEF、NF-proBNP影响

Effects of Ivabradine Combined with Metoprolol on Blood gas LVEF and NFproBNP in Patients with CHF

目的研究伊伐布雷定联合美托洛尔对慢性心力衰竭(CHF)患者血气及左心室射血分数(LVEF)、血浆氨基酸末端脑钠肽前体(NF-proBNP)影响。方法回顾性分析2017年1月至2019年8月江苏省省级机关医院收治的50例CHF患者,按不同治疗方式分为观察组(n=27)与参照组(n=23)。参照组采用美托洛尔治疗,观察组在参照组基础上给予依伐布雷定。周期4周。对比2组血气、HR、LVEF、NF-proBNP水平及生活质量、不良反应。结果与治疗前比,治疗后2组血氧分压(PaO2)、血氧饱和(SaO2)水平升高,观察组高于参照组(P<0.05);2组PaCO2水平降低,观察组低于参照组(P<0.05)。治疗后2组HR、NF-proBNP水平下降,观察组低于参照组(P<0.05);2组LVEF水平升高,观察组高于参照组(P<0.05)。治疗后观察组情绪、交际、运动及心理评分高于参照组(P<0.05)。结论依伐布雷定联合美托洛尔可改善CHF患者血气指标,保护心功能,提高生活质量,减少不良反应。

Objective To study the effect of ivabradine combined with metoprolol on blood gas,LVEF and NFproBNP in patients with CHF.Methods A retrospective analysis was made of 50 CHF patients admitted to Jiangsu Provincial Government Hospital from January 2017 to August 2019.According to the treatment,they were divided into observation group(n=27)and reference group(n=23).The control group was treated with metoprolol,and the observation group was treated with ivabradine.Cycle 4 weeks.Blood gas,HR,LVEF,NF-proBNP,quality of life and adverse reactions were compared before and after treatment.Results Compared with the before treatment,the PaO2 and SaO2 in the observation group were higher than those in the reference group(P<0.05);the PaO2 in the observation group were lower than those in the reference group(P<0.05).After treatment,the HR and NFproBNP water in the observation group were lower than those in the reference group(P<0.05),and the LVEF level in the observation group was higher than that in the reference group(P<0.05).After treatment,the scores of emotion,communication,sports and psychology observation group was higher than those of the reference group(P<0.05).Conclusion Ivabradine combined with metoprolol can improve the blood gas index of patients with chronic heart failure,protect the heart function,improve the quality of life and reduce adverse reactions.