阿奇霉素序贯疗法对肺炎支原体肺炎患儿喘咳恢复及肺功能的影响

Effects of Azithromycin Sequential Therapy on Recovery of Asthma and Lung Function in Children with Mycoplasma Pneumoniae Pneumonia

目的探讨阿奇霉素序贯疗法对肺炎支原体肺炎患儿喘咳恢复及肺功能的影响。方法选取2016年1月至2019年5月苏州市常熟市梅李人民医院收治的肺炎支原体肺炎患儿95例,按照治疗方法的不同分为对照组(n=48)和观察组(n=47),对照组给予阿奇霉素口服疗法,观察组给予阿奇霉素序贯疗法。2组均治疗7 d。比较2组临床疗效、症状改善情况及不良反应发生情况,比较2组治疗前后肺功能变化。结果观察组与对照组临床总有效率、症状改善时间差异无统计学意义(P>0.05);与治疗前相比,2组第一秒用力呼气容积及最大呼气流量(PEF)均升高(P<0.05),但组间比较差异无统计学意义(P>0.05);观察组不良反应总发生率6.39%明显少于对照组22.92%(P<0.05)。结论阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎在保证临床疗效的基础上能降低不良反应发生率,提高安全性。

Objective To investigate the effects of azithromycin sequential therapy on recovery of asthma and lung function in children with Mycoplasma pneumoniae pneumonia.Methods Totally 95 children with Mycoplasma pneumoniae pneumonia treated in Meili People's Hospital of Changshu City from January 2016 to May 2019 Suzhou were selected and divided into control group(n=48)and observation group(n=47)according to different treatment methods.The group was given azithromycin sequential therapy.Both groups were treated for 7 days.The clinical efficacy,symptom improvement and adverse reactions were compared between the two groups,and the changes in lung function before and after treatment were compared between the two groups.Results There was no significant difference in the total clinical effective rate and the time for improvement of symptoms between the observation group and the control group(P>0.05).Compared with before treatment,the forced expiratory volume and PEF in the first second of the two groups were increased(P<0.05),but There was no significant difference between the groups(P>0.05).The total incidence of adverse reactions in the observation group was 6.39%,which was significantly lower than that in the control group 22.92%(P<0.05).Conclusion Sequential therapy of azithromycin in children with Mycoplasma pneumoniae pneumonia reduces the incidence of adverse reactions on the basis of ensuring clinical efficacy,improves safety.