四君子汤对气虚体质脑梗死恢复期患者神经功能及血清hs-CRP、TNF-α水平的影响

Effect of Sijunzi Decoction on Neurological Function and Serum Hs-CRP and TNF-α Levels in Patients with Qi-deficiency Constitutional Cerebral Infarction

目的 探究四君子汤对气虚体质脑梗死恢复期患者神经功能及血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平的影响.方法 回顾性分析常州市武进中医院2016年1月至2017年9月收治的68例气虚体质脑梗死恢复期患者,按治疗方法 不同分为治疗组和对照组,各34例.对照组给予阿司匹林治疗,治疗组在对照组基础上联合四君子汤,2组均随访6个月.比较2组治疗前、随访6个月中医症状评分;比较2组治疗前、随访第30d血清hs-CRP、TNF-α水平;采用美国国立卫生研究研究所卒中量表(NIHSS)比较2组治疗前、随访3、6个月评分;比较2组随访6个月期间卒中再发生率.结果 与治疗前相比,随访6个月治疗组中医症状评分降低,且治疗组低于对照组;与治疗前相比,随访第30d2组血清hs-CRP、TNF-α水平降低,且治疗组低于对照组;与治疗前相比,随访3~6个月2组NIHSS评分逐渐降低,且治疗组低于对照组(均P<0.05).随访6个月期间治疗组卒中再发生率8.82%低于对照组(12.12%,P>0.05).结论 四君子汤能降低气虚体质脑梗死恢复期患者血清hs-CRP、TNF-α水平,可调节患者的神经功能.

Objective To explore the effect of Sijunzi Decoction on neurological function and serum hs-CRP and TNF-αlevels in patients with Qi-deficiency constitutional cerebral infarction.Methods Retrospective analysis was performed on 68 convalescent patients with cerebral infarction with qi-deficiency constitution admitted to changzhou wujin hospital of traditional Chinese medicine from January 2016 to September 2017.According to different treatment methods,they were divided into treatment group and control group,with 34 cases in each.The control group was given aspirin treatment,and the treatment group was combined with sijunzi decoction on the basis of the control group.The two groups were followed up for 6 months.The TCM symptom scores of the two groups were compared before treatment and followed up for 6 months.Serum levels of hs-crp and TNF-were compared between the two groups before treatment and at the 30th day of follow-up.NIHSS scores before treatment,3 and 6 months of follow-up were compared between the two groups.The incidence of stroke recurrence was compared between the two groups during the 6-month follow-up period.Results Compared with that before treatment,the TCM symptom scores of the treatment group was decreased during the 6-month follow-up,and those in the treatment group were lower than those in the control group;Compared with before treatment,serum hs-CRP and TNF-αlevels in the two groups were decreased on the 30th day of follow-up,and the level in the treatment group was lower than that in the control group;Compared with before treatment,NIHSS score of the two groups was gradually decreased during the follow-up period of 3~6 months,and that of the treatment group was lower than that of the control group(all P<0.05).The recurrence rate of stroke in the treatment group 8.82%was lower than that in the control group(12.12%,P>0.05).Conclusion Sijunzi Decoction can decrease serum hs-CRP and TNF-αlevels in patients with Qi-deficiency constitutional cerebral infarction and can regulate the neurological function of patients.