拉贝洛尔对妊娠期高血压疾病患者血清BUN、CysC、UA、SCr水平的影响

Effect of Labelor on Serum BUN,CysC,UA and SCr in Pregnant Patients with Hypertension

目的 探讨拉贝洛尔对妊娠期高血压疾病患者血清尿素氮(BUN)、胱抑素C(CysC)、尿酸(UA)与肌酐(SCr)水平的影响.方法 选取2018年1月至2019年9月赣榆区妇幼保健院收治的72例妊娠期高血压疾病患者,按照随机数字表法分成实验组和对照组,各36例.对照组采用硝苯地平,实验组在对照组的基础上加用拉贝洛尔,均治疗14d.比较治疗14d后2组临床疗效,比较治疗前及治疗14d后2组收缩压、舒张压及血清BUN、CysC、UA、SCr水平变化,比较治疗过程中2组并发症发生情况.结果 治疗后,实验组总有效率(97.22%)显著高于对照组(80.56%,P<0.05);与治疗前相比,治疗后2组收缩压、舒张压均下降,且实验组显著低于对照组(P<0.05);与治疗前相比,治疗后2组血清CysC、BUN、UA、SCr水平均降低,且实验组显著低于对照组(P<0.05);实验组并发症发生率(11.11%)显著低于对照组(58.33%,P<0.05).结论 拉贝洛尔可有效降低妊娠高血压患者血压,改善肾功能,减少并发症,疗效显著.

Objective To investigate the effect of labelor on serum urea nitrogen(BUN),cystatin C(CysC),uric acid(UA)and creatinine(SCr)levels in patients with gestational hypertension.Methods A total of 72 patients with gestational hypertension admitted to ganyu district maternal and child health hospital from January 2018 to September 2019 were selected.The control group was treated with nifedipine,and the experimental group was treated with labelor on the basis of the control group.The clinical efficacy of the two groups after 14 days of treatment was compared,the changes of systolic blood pressure,diastolic blood pressure and serum BUN,CysC,UA and SCr levels in the two groups before and after 14 days of treatment were compared,and the occurrence of complications in the two groups during the treatment was compared.Results After treatment,the total effective rate of the experimental group(97.22%)was significantly higher than that of the control group(80.56%,P<0.05).Compared with before treatment,systolic and diastolic blood pressure in the two groups decreased after treatment,and the experimental group was significantly lower than the control group(P<0.05).Compared with before treatment,serum levels of CysC,BUN,UA and SCr in the two groups all decreased after treatment,and the experimental group was significantly lower than the control group(P<0.05).The incidence of complications in the experimental group(11.11%)was significantly lower than that in the control group(58.33%,P<0.05).Conclusion Labelor can effectively reduce blood pressure,improve renal function and reduce complications in patients with gestational hypertension.