滋肾益髓方联合西药治疗帕金森氏病患者非运动症状的疗效观察

Therapeutic effect of Zishen Yisui Decoction combined with Western medicine on non-motor symptoms of parkinson’s disease

[目的]探讨滋肾益髓方联合西药治疗帕金森氏病患者非运动症状的疗效。[方法]选用证型为髓海不足证的帕金森氏病患为研究对象,进行前瞻性平行对照试验,按治疗组、对照组1∶1共计60例,其中治疗组30例,对照组30例。治疗组采用中西医结合疗法,给予滋肾益髓方药联合西药(标准左旋多巴剂量),对照组维持仅口服西药治疗,观察周期为1个月,停药后随访3个月。在治疗过程中通过帕金森病统一评定量表(UPDRS)及30项非运动症状筛查问卷(NMSQ)等国际公认的评价体系评估患者的临床症状,采用对比分析法评定疗效。[结果]与治疗前对比,治疗组病患治疗后不同时间内的UPDRS总评分值、NMSQ评分值均有明显下降,与治疗前相比具有统计学意义(P<0.05)。[结论]滋肾益髓方联合西药治疗帕金森氏病患非运动症状的疗效确切。

[Objective]To explore the curative effect of Zishen Yisui Decoction combined with western medicine on non-motor symptoms of Parkinson’s disease.[Methods]A prospective parallel control trial was conducted in 60 patients with Parkinson's disease with syndrome type of insufficiency of medullary sea as the research object.According to the treatment group,there were 60 patients in the control group,thirty in the treatment group and thirty in the control group.The treatment group was treated with the combination of traditional Chinese and Western medicine,Zishen Yisui Decoction combined with western medicine(standard dosage of levodopa).The control group was treated with oral western medicine only.The observation period was one month,and the follow-up period was 3 months after withdrawal.In the course of treatment,the clinical symptoms were evaluated by Unified Parkinson's disease rating scale(UPDRS)and Non-motor symptom screening questionnaire(NMSQ),and the curative effect was evaluated by comparative analysis.[Results]Compared with before treatment,the total UPDRS score and NMSQ score of patients in the treatment group decreased significantly in different time after treatment,with statistical significance compared with before treatment(P<0.05).[Conclusion]Zishen Yisui Decoction combined with western medicine is effective in treating non-motor symptoms of Parkinson's disease.