长链非编码RNAs与缺血性脑卒中关系的研究进展

Relationship between long non-coding RNAs and ischemic stroke

缺血性脑卒中发病率、致残率、病死率均较高,治疗时间窗窄,深入研究其发病机制,有助于发现新的治疗靶点。长链非编码RNAs (long non-coding RNAs, lncRNAs)通过钙超载、氧化应激、炎性反应、神经血管损伤、神经元坏死、突触功能破坏等过程参与缺血性脑卒中的进展,在缺血性脑卒中诊断及预后评估中具有重要作用。本文就lncRNAs参与缺血性脑卒中神经元细胞、血管内皮细胞、小胶质细胞的调控机制,缺血性脑卒中相关lncRNAs表达的研究进展作一综述。

Ischemic stroke, characterized by high mortality, disability and morbidity, has narrow therapeutic time window, so a further and thorough study on the pathologic mechanism is helpful for the discovery of novel therapeutic targets. Long non-coding RNAs(lncRNAs) play an important role in both diagnosis and prognosis prediction of ischemic stroke, and participate in the progression of ischemic stroke through calcium overload, oxidative stress, inflammatory responses, neurovascular injury, neuron necrosis, destruction of synaptic function and so on. This paper reviews the research progress of the mechanisms of lncRNAs in the regulation of neurons, vascular endothelial cells and microglia in processes of ischemic stroke, and lncRNAs expression related with ischemic stroke.