PCI中采用药物涂层球囊的拘禁球囊技术对冠状动脉分叉病变边支的保护效果

Protective effect of jailed balloon technique using drug-coated balloon on the side branch of coronary artery bifurcation lesions after percutaneous coronary intervention

目的评价采用药物涂层球囊(DCB)的拘禁球囊技术(JBT)在冠状动脉分叉病变PCI中保护边支的安全性、即刻疗效和远期疗效.方法将60例冠状动脉分叉病变患者分为DCB组(29例)与普通球囊(CB)组(31例).DCB组采用DCB在JBT条件下处理边支,CB组采用CB在JBT条件下处理边支.对比2组手术的安全性、即刻疗效和远期疗效.结果2组患者基线资料比较差异无统计学意义(P均>0.05).术后9个月,DCB组边支的血管最小管径大于CB组[(1.987±0.206)cm vs.(1.840±0.186)cm,P<0.05],DCB组边支的晚期管腔丢失小于CB组[(0.003±0.074)cm vs.(0.062±0.064)cm,P<0.05],DCB组LVEF恢复情况优于CB组[(56.07±4.527)%vs.(52.61±3.65)%,P<0.05].结论与CB比较,DCB在JBT条件下对处理冠状动脉分叉病变中边支介入治疗安全有效,能保护边支血管,提高患者心脏收缩功能,远期疗效更优.

Objective To evaluate the safety,immediate efficacy and late efficacy of jailed balloon technique(JBT)using a drug-coated balloon(DCB)in the protection of the side branch of coronary artery bifurcation lesions after percutaneous coronary intervention(PCI).Methods Sixty patients with coronary bifurcation were enrolled and divided into the DCB(n=29)and conventional balloon(CB)groups(n=31).In the DCB group,patients were treated with JBT using DCB,and those in the CB group were treated with JTB using CB.The safety,immediate efficacy and late efficacy were statistically compared between two groups.Results The baseline data did not significantly differ between two groups(all P>0.05).At postoperative 9 months,the minimal lumen diameter(MLD)of the side branches in the DCB group was significantly longer than that in the CB group,(1.987±0.206)cm vs.(1.840±0.186)cm,P=0.005.The late lumen loss(LLL)of side branches in the DCB group was significantly less than that in the CB group,(0.003±0.074)cm vs.(0.062±0.064)cm,P<0.05.The recovery of left ventricular ejection fractions(LVEF%)in the DCB group was considerably better than that in the CB group,(56.07±4.527)%vs.(52.61±3.65)%,P<0.05.Conclusion Compared with JBT using CB,JBT using DCB is safer and more effective in the treatment of the side branch of coronary artery bifurcation lesions after PCI which can better protect the side branches,improve the cardiac systolic function and yield higher late efficacy.