2型糖尿病患者血糖波动与鸢尾素水平的关系

The relationship between blood glucose fluctuation and the level of irisin in type 2 diabetes mellitus patients

目的分析2型糖尿病患者血糖波动与鸢尾素水平之间的关系。方法选取102例2018年3月至2019年6月在我院治疗的2型糖尿病患者,将其随机分为对照组和观察组,各51例,对照组患者给予单纯的二甲双胍治疗,观察组患者在对照组的基础上联合阿卡波糖治疗,观察并比较两组患者的基本资料、治疗前后血糖水平[空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抗性指标、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇等(LDL-C)]变化情况以及其鸢尾素水平的变化情况。结果对照组治疗过程中应用胰岛素24例,观察组9例,组间差异有统计学意义(P<0.05);治疗后,两组患者的血糖水平、胰岛素抗性指标都有所改善,与治疗前相比较差异有统计学意义(P<0.05),且观察组改善的幅度大于对照组,2组相比较差异有统计学意义(P<0.05);治疗后,观察组患者鸢尾素水高于对照组,观察组TG水平高于对照组,TC、HDL-C、LDL-C低于对照组,差异有统计学意义(P<0.05);相关性分析结果显示,鸢尾素水平与患者空腹血糖、餐后2 h血糖以及糖化血红蛋白均呈负相关(r分别=-0.501、-0.436、-0.564,P<0.05)。结论采用二甲双胍联合阿卡波糖治疗2型糖尿病患者,能够有效改善患者的血糖水平,增高鸢尾素水平,治疗效果显著,有较高的推广价值。

Objective To analyze the relationship between blood glucose fluctuation and the level of irisin in type 2 diabetes mellitus patients.Methods One hundred and two patients with type 2 diabetes treated in our hospital from March 2018 to June 2019 were selected,which were randomly divided into control group(51 cases)and observation group(51 cases).The patients of the control group were treated with simple metformin treatment,and on the basis of the control group,the patients of the observation group were treated with acarbose treatment.Weobserved and compared the basic data of two groups of patients and blood indicatorslevels before and after the treatment(fasting blood glucose,postprandial 2 h blood glucose,glycatedhemoglobin,insulin resistance index,cholesterol,triglyceride,high-density lipoprotein cholesterol,low density lipoprotein cholesterol,etc.)and the changes of the irisin.Results During the treatment,24 cases were treated with insulin in the control group and 9 cases in the observation group,and the differences between the groups were statistically significant(P<0.05).After treatment,the blood glucose level and insulin resistance index of the two groups were improved,and the difference was significant compared with that before treatment(P<0.05),and the improvement range of the observation group was greater than that of the control group,and the difference between the two groups was significant(P<0.05).After treatment,the level of irisin and TG in the observation group was higher than thosein the control group,and the TC,HDL-Cand LDL-C werelower than thosein the control group,the differences were significant(P<0.05).Correlation analysis showed that irisinlevels were negatively correlated with fasting blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin,respectively(r=-0.501,-0.436,-0.564,P<0.05).Conclusion The blood glucose level of diabetic patients was negatively correlated with serum irisin significantly.Clinical use of metformin combined with acarbose in the treatment of type 2 diabetic patients can effectively improve the blood glucose level of patients,increase the level of irisin.The treatment effect is significantand it has a high value of promotion.