坎地沙坦与阿利沙坦酯在原发性高血压患者治疗中的应用效果比较

Comparison of Candesartan and Alishartan Ester in the Treatment of Essential Hypertension

目的分析坎地沙坦与阿利沙坦酯在原发性高血压患者治疗中的应用效果。方法筛选140例原发性高血压病患,按照用药方法不同,将患者分为坎地沙坦组和阿利沙坦酯组,对比两组患者的用药效果、血压水平和不良反应。结果两组患者用药后的舒张压与收缩压水平均低于用药前,用药前后存在明显差异(P<0.05);两组患者用药后的舒张压与收缩压水平以及临床总有效率差异无统计学意义(P>0.05)。阿利沙坦酯组用药过程不良反应发生率对于坎地沙坦组,差异有统计学意义(P<0.05)。结论原发性高血压应用坎地沙坦与阿利沙坦酯治疗均能够获得满意的降压效果,阿利沙坦不良反应相对较少,值得推广应用。

Ojective To analyze the effect of candesartan and alizartan ester in the treatment of essential hypertension.Methods 140 patients with essential hypertension were selected.According to the different medication methods,the patients were divided into two groups:candesartan group and alizartanate group.The effect of medication,blood pressure level and adverse reactions of the two groups were compared.Results The diastolic blood pressure and systolic blood pressure of the two groups after treatment were lower than those before treatment,and there were significant differences before and after treatment(P<0.05);there was no significant difference between the two groups in the level of diastolic blood pressure and systolic blood pressure and clinical total effective rate(P>0.05).There were significant differences in the incidence of adverse drug reactions between the two groups(P<0.05).Conclusion Both candesartan and alizartan can achieve satisfactory antihypertensive effect in patients with essential hypertension,and the adverse reactions of alizartan are relatively few,which is worthy of application.