儿童包皮术后在不同条件下应用重组牛碱性纤维细胞因子的临床疗效观察

Clinical Observation of the Application of Recombinant Bovine Basic Fibrosis Cytokines Under Different Conditions in Children After Circumcision

目的探讨儿童包皮术后在不同条件下应用重组牛碱性纤维细胞因子的临床疗效。方法选取本院2018年1月至2019年1月收治的包皮环切术患儿98例,将切口有炎性介质的49例患儿纳入观察组,将切口无炎性介质的49例患儿纳入对照组,两组术后采用重组牛碱性纤维细胞因子涂抹切口,比较两组瘢痕平整度、切口愈合时间、疼痛程度。结果对照组瘢痕平整率(93.88%)较观察组(71.43%)高,差异具有统计学意义(P<0.05);对照组切口愈合时间(5.11±0.43)d、术后1d VAS评分(1.69±0.22)分,较观察组[(6.95±0.41)d、(2.82±0.26)d]低,差异具有统计学意义(P<0.05)。结论儿童包皮术后在无炎性介质时应用重组牛碱性成纤维细胞生长因子更有促进创面愈合和新鲜创面的疗效,起到薄膜作用与外界隔离,缩短疗程,安全性高,可行性好。

Objective To investigate the clinical efficacy of recombinant bovine basic fibrin cytokine under different conditions in children with foreskin surgery.Methods A total of 98 children with circumcision admitted to our hospital from January 20 to January 2019 were enrolled.49 children with inflammatory mediators were included in the observation group,and 49 patients with non-inflammatory mediators were included.In the control group,the incision was made by recombinant bovine basic fibrin cytokine after operation,and the degree of scar flatness,time of incision healing and pain degree were compared between the two groups.Results The scar flatness rate of the control group(93.88%)was higher than that of the observation group(71.43%),and the difference was statistically significant(P<0.05).The incision healing time of the control group(5.11±0.43)d and the postoperative 1d VAS score(1.69±0.22)was lower in the observation group[(6.95±0.41)d,(2.82±0.26)d],and the difference was statistically significant(P<0.05).Conclusion The application of recombinant bovine basic fibroblast growth factor in the absence of inflammatory mediators in children with foreskin can promote the healing of wounds and fresh wounds.It can separate the membrane from the outside,shorten the course of treatment,calm and repair scars,and safety.High and feasible.