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脑肠互动障碍及其相关生物-心理-社会因素对肠易激综合征病理生理影响的研究进展 被引量:8

Progress on the Pathophysiological Effects of Brain-Bowel Interaction Disorder and Its Related Bio-Psycho-Social Factors on Irritable Bowel Syndrome
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摘要 肠易激综合征(IBS)是一种常见的功能性胃肠疾病,主要表现为腹痛、腹胀、胃肠不适,常伴有大便次数异常增多等症状,并呈现一定程度的精神心理共病(如焦虑和抑郁),其发病机制和病理生理学变化尚未阐明。多项研究显示IBS是由于中枢神经系统与胃肠之间的脑肠轴功能紊乱,导致身心失衡,进而产生一系列心理和胃肠道病理表现。本文主要总结了近三年关于脑肠互动障碍及其相关的生物-心理-社会因素(脑肠肽、神经内分泌轴、肠道微生物、免疫调节系统、精神心理疾病)对IBS病理生理的影响,同时为IBS的预防和治疗提供方向。
作者 齐雯丽 綦钰莹 李玲珑 邹飞 Qi Wenli;Qi Yuying;Li Linglong
出处 《巴楚医学》 2020年第1期121-125,共5页 Bachu Medical Journal
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