奥美拉唑与雷尼替丁治疗消化性溃疡临床疗效的对比研究

A Comparative Study of the Clinical Efficacy of Omeprazole and Ranitidine in the Treatment of Peptic Ulcer

目的分析研究奥美拉唑与雷尼替丁治疗消化性溃疡临床疗效。方法选取本院2017年4月至2018年7月收治的106例消化性溃疡患者进行此次研究,按照数字表法将所有患者均分为参照组和研究组两组,各53例。其中给予雷尼替丁治疗的为参照组,联合应用奥美拉唑与雷尼替丁治疗的为研究组,比较两组的治疗效果、复发率以及Hp根除率。结果参照组治疗后的治疗总有效率(81.13%)低于研究组(94.34%)且差异显著(P<0.05);研究组治疗后的复发率(5.66%)低于参照组(24.53%),Hp根除率(90.57%)高于参照组(73.58%)且差异显著(P<0.05)。结论联合应用奥美拉唑与雷尼替丁治疗消化性溃疡,能够显著提升治疗效果显,值得临床治疗中加大推广和采用力度。

Objective To study the clinical effi cacy of omeprazole and ranitidine in the treatment of peptic ulcer.Methods 106 patients with peptic ulcer admitted to our hospital from April 2017 to July 2018 were selected for this study.According to the digital table method,all patients were divided into the reference group and the research group,53 cases in each group.The control group was treated with ranitidine,and the study group was treated with omeprazole and ranitidine.The therapeutic effect,recurrence rate and eradication rate of Hp were compared between the two groups.Results The total effective rate(81.13%)of the control group after treatment was lower than that of the study group(94.34%)and the difference was signifi cant(P<0.05);the recurrence rate(5.66%)of the study group after treatment was lower than that of the control group(24.53%),and the eradication rate of Hp(90.57%)was higher than that of the control group(73.58%)and the difference was signifi cant(P<0.05).Conclusion The combination of omeprazole and ranitidine in the treatment of peptic ulcer can signifi cantly improve the therapeutic effect,which is worthy of further promotion and application in clinical treatment.