达格列净治疗2型糖尿病的疗效及其对体质指数的影响

The Therapeutic Effect of Dapagliflozin on Type 2 Diabetes and Its Influence on Body Mass Index

目的观察达格列净治疗2型糖尿病的疗效、安全性及其对体质指数的影响。方法选取2017年4月~12月在我院诊治的153例2型糖尿病患者为研究对象,采用随机数字表法分为对照组(n=75)和观察组(n=78)。对照组采用二甲双胍治疗,观察组采用达格列净治疗,比较两组治疗疗效、治疗后空腹血糖(FBG)水平、糖化血红蛋白(HbA1c)、体重指数(BMI)、血压、肾功能指标[尿酸(UA)、尿微量白蛋白(mAlb)]、病死率及低血糖发生率。结果观察组治疗总有效率为93.50%,与对照组的92.10%比较,差异无统计学意义(P>0.05);观察组FBG、HbA1c、BMI、收缩压、舒张压均低于对照组,差异有统计学意义(P<0.05);观察组UA、mAlb水平均低于对照组,差异有统计学意义(P<0.05);观察组病死率低于对照组,差异有统计学意义(P<0.05),两组低血糖发生率比较,差异无统计学意义(P>0.05)。结论达格列净治疗2型糖尿病效果确切,对肾功能影响较小,病死率低,有助于改善患者预后,安全性较好。

Objective To observe the efficacy and safety of dapagliflozin in the treatment of type 2 diabetes and its impact on body mass index.Methods A total of 153 patients with type 2 diabetes diagnosed and treated in our hospital from April to December 2017 were selected as the research object,and were divided into a control group(n=75)and an observation group(n=78)by random number table.The control group was treated with metformin,and the observation group was treated with dapagliflozin.The therapeutic effect,fasting blood glucose(FBG)level,glycated hemoglobin(HbA1c),body mass index(BMI),blood pressure,and renal function indexes[uric acid(UA),microalbuminuria(mAlb)],mortality and incidence of hypoglycemia.Results The total effective rate of treatment in the observation group was 93.50%,compared with 92.10%in the control group,the difference was not statistically significant(P>0.05);FBG,HbA1c,BMI,systolic blood pressure and diastolic blood pressure in the observation group were lower than the control group,the difference was statistically significant(P<0.05);the UA and mAlb levels of the observation group were lower than the control group,the difference was statistically significant(P<0.05);the mortality rate of the observation group was lower than the control group,the difference was statistically significant(P<0.05),the incidence of hypoglycemia between the two groups was not statistically significant(P>0.05).Conclusion Dapagliflozin has a definite effect on the treatment of type 2 diabetes.It has little effect on renal function and low mortality.