稳心调脂汤对冠心病合并高脂血症患者中医证候及血脂水平的影响

Effect of Wenxin Tiaozhi Decoction on TCM Syndromes and Blood Lipid Levels in Patients with Coronary Heart Disease and Hyperlipidemia

目的研究稳心调脂汤治疗冠心病合并高脂血症对中医证候及血脂水平的影响。方法选取2018年1月~2019年7月在我院诊治的88例冠心病合并高脂血症患者为研究对象,采用随机数字表法分为对照组和观察组,各44例。对照组采用阿司匹林联合富马酸比索洛尔治疗,观察组在对照组基础上联合稳心调脂汤治疗,比较两组临床治疗总有效率、血脂[血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平、中医证候积分及安全性。结果观察组治疗总有效率为95.45%,高于对照组的81.81%,差异有统计学意义(P<0.05);治疗后两组TC、TG、LDL-C均低于治疗前,且观察组低于治疗组,差异有统计学意义(P<0.05);治疗后两组HDL-C均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后两组胸闷、胸痛、心悸、气促、疲倦乏力证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为2.27%与对照组的4.54%比较,差异无统计学意义(P>0.05)。结论稳心调脂汤可提高对冠心病合并高脂血症临床治疗疗效,改善血脂水平,减轻中医证候,且应用不良反应少,值得临床应用。

Objective To study the effect of Wenxin Tiaozhi Decoction on coronary heart disease with hyperlipidemia on TCM syndromes and blood lipid levels.Methods A total of 88 patients with coronary heart disease and hyperlipidemia diagnosed and treated in our hospital from January 2018 to July 2019 were selected as the research object.They were divided into a control group and an observation group with a random number table method,44 cases each.The control group was treated with aspirin and bisoprolol fumarate,and the observation group was combined with Wenxin Tiaozhi Decoction on the basis of the control group.The total clinical efficacy,serum lipids[serum total cholesterol(TC),Triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]levels,TCM syndrome scores and safety.Results The total effective rate of treatment in the observation group was 95.45%,which was higher than 81.81%in the control group,the difference was statistically significant(P<0.05);after treatment,the TC,TG,LDL-C of the two groups were lower than before treatment,and the observation group was low In the treatment group,the difference was statistically significant(P<0.05);after treatment,the HDL-C in both groups was higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);two after treatment The syndrome scores of chest tightness,chest pain,palpitations,shortness of breath,fatigue and fatigue were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 2.27%and compared with 4.54%of the control group,the difference was not statistically significant(P>0.05).Conclusion Wenxin Tiaozhi Decoction can improve the curative effect of coronary heart disease combined with hyperlipidemia,improve the level of blood lipids,reduce the symptoms of traditional Chinese medicine,and have fewer adverse reactions.