CA153、CA125联合HER-2检测在乳腺癌各临床分期诊断中的应用

Application of CA153 and CA125 Combined with HER-2 Detection in the Diagnosis of Breast Cancer in Different Clinical Stages

目的分析糖类抗原125(CA125)、糖类抗原153(CA153)联合人类表皮生长因子-2(HER-2)检测在乳腺癌各临床分期诊断中的应用价值。方法选取2016年5月~2019年5月在我院诊治的200例乳腺癌患者为研究对象,另选取同期体检健康者60名为对照组,比较对照组与乳腺癌各临床分期CA125、CA153及HER-2水平,肿瘤标志物单项检测与三者联合检测的阳性率、敏感性、特异性、准确度。结果乳腺癌各临床分期患者CA125、CA153、HER-2水平均高于对照组,且Ⅲ期、Ⅳ期乳腺癌患者CA125、CA153、HER-2水平高于Ⅰ~Ⅱ期(P<0.05);乳腺癌各临床分期患者CA153+CA125+HER-2联合检测的阳性率高于任一单项检测,且各肿瘤标志物随临床分期的增加阳性率升高(P<0.05);乳腺癌患者CA153+CA125+HER-2联合检测的敏感性、准确度高于单项检测(P<0.05);CA153+CA125+HER-2联合检测特异性与单项检测比较,差异无统计学意义(P>0.05)。结论CA153、CA125、HER-2水平与乳腺癌分期可能有关,且随乳腺癌不同分期增加阳性率逐渐升高,三者联合检测对乳腺癌诊断具有较好的敏感性和准确度。

Objective To analyze the application value of carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)combined with human epidermal growth factor-2(HER-2)detection in the clinical staging diagnosis of breast cancer.Methods 200 patients with breast cancer diagnosed and treated in our hospital from May 2016 to May 2019 were selected as the research object,and 60 healthy persons who were healthy during the same period were selected as the control group.Compare the levels of CA125,CA153 and HER-2 in each clinical stage of the control group and breast cancer,the positive rate,sensitivity,specificity and accuracy of single detection of tumor markers and the combined detection of the three.Results The levels of CA125,CA153,and HER-2 in patients with breast cancer in different clinical stages were higher than those in the control group,and the levels of CA125,CA153,and HER-2 in patients with stage III and stage IV breast cancer were higher than those in stages I to II(P<0.05);the positive rate of CA153+CA125+HER-2 combined detection of breast cancer patients in each clinical stage was higher than any single test,and the positive rate of each tumor marker increased with the increase of clinical stage(P<0.05);the sensitivity and accuracy of combined detection of CA153+CA125+HER-2 in breast cancer patients is higher than that of single detection(P<0.05);The specificity of the CA153+CA125+HER-2 combined test was not statistically different from the single test(P>0.05).Conclusion The levels of CA153,CA125 and HER-2 may be related to the stage of breast cancer,and the positive rate gradually increases with the increase of different stages of breast cancer.The combined detection of the three has good sensitivity and accuracy in the diagnosis of breast cancer.