基于EVs的肿瘤诊断,距离真正的临床应用还有多远

How far is the clinical application of EVs-based tumor diagnosis?

作为一种新型的旁/自分泌及远程信号传导方式,细胞外囊泡(EVs)几乎参与了肿瘤发生、进展、转移、耐药等整个过程,对肿瘤诊疗产生了极大的启发。EVs具有作为血液或尿液生物标志物的强大潜力,可用于癌症的诊断、预后和监测。由于在临床上的巨大应用价值,近几年EVs成为肿瘤研究的热点。因此,本文讨论了EVs标志物在肿瘤临床诊断中的优势、进展方向和技术挑战。

As a new type of paracrine/autocrine and remote signaling,extracellular vesicles(EVs)involved in almost the whole process of tumorigenesis,progression,metastasis,and drug resistance,which has greatly inspired tumor diagnosis and treatment.EVs have the great potential to be the blood or urine biomarkers and can be used for cancer diagnosis,prognosis and monitoring.Due to its great clinical application value,EVs have become a hotspot in cancer research in recent years.Therefore,in this review,the advantages,progression,and technical challenges of EVs biomarkers in clinical tumors diagnosis are discussed.