Glypican-3与肝癌关系的研究现状与进展

Research status and progress of Glypican-3 and liver carcinoma

磷脂酰肌醇蛋白聚糖-3(GPC3)是一种细胞表面硫酸乙酰肝素蛋白多糖,属于与甘氨酸相关的整体膜蛋白多糖亲缘蛋白。很多研究表明,GPC3在肝癌的发生、诊断、治疗、预后等方面有重要意义,本文将对近几年来GPC3的相关研究作一综述。

Phosphatidylinositol protein 3(Glypican-3,GPC3)is a cell-surface heparan sulfate proteoglycan that belongs to the glycine related global membrane proteoglycan relatives.Many studies have shown that it is of great significance in the occurrence,diagnosis,treatment and prognosis of hepatocellular carcinoma(HCC).This paper reviews the recent studies on GPC3.