摘要
TREK-1是双孔背景钾通道(tow-pore domain K^+channel,K2P)成员之一,参与调控细胞静息膜电位等,有着多种功能特性。近年来研究表明,TREK-1在麻醉、疼痛、神经保护和抑郁方面有着极其重要的作用。文章综合国内外TREK-1相关文献,简要概述TREK-1结构、功能、分布和调控,重点介绍TREK-1在上述领域的研究进展。通过进一步阐述TREK-1在麻醉、疼痛、神经保护和抑郁领域的作用,可以更好地认识TREK-1在其中的病理意义,并有助于新药物的开发。
TREK-1,a member of two-pore domain K^+channel(K2P)family,has various functions and participates in the regu-lation of resting membrane potentials.Recent studies indicate that TREK-1 is essential in anesthesia,pain,neuroprotection and depres-sion.Based on domestic and foreign literature related to TREK-1,this review concisely outlines the structure,function,distribution and modulation of TREK-1,and thoroughly presents the advances in those fields above.Furthermore,the role of TREK-1 in general anes-thesia,pain,neuroprotection and depression has been elaborated,so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs.
作者
赵帅
欧阳晔凌
胡志强
陈向东
姚尚龙
Zhao Shuai;Ouyang Yeling;Hu Zhiqiang;Chen Xiangdong;Yao Shanglong(Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《国际麻醉学与复苏杂志》
CAS
2020年第1期105-110,共6页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81571075,81371249)。
关键词
TREK-1
双孔背景钾通道
麻醉
疼痛
神经保护
抑郁
TREK 1
Tow pore domain K+channel
Anesthesia
Pain perception
Neuroprotection
Depression
