儿童侵袭性真菌感染的研究进展

Recent developments of invasive fungal infections in children

高风险患者中侵袭性真菌感染(IFIs)的发病率及死亡率很高。早期诊断和治疗可以有效降低IFIs的死亡率。然而,由于其缺乏特异性的临床症状和体征,早期诊断IFIs通常会很困难。因此即使没有IFIs的确诊证据,对于符合条件的高危患者也仍有必要进行早期抗真菌治疗。本文综述了儿童IFIs的临床症状和体征及诊断方法的相关研究进展,旨在为IFIS的早期诊断、改善疾病的转归、减轻疾病负担提供线索和支持。

The morbidity and mortality of invasive fungal infections(IFIs) in high-risk patients are very high. The mortality can be effectively reduced by an early diagnosis and treatment. However,it is often difficult to recognize IFIs because of non-specific clinical symptoms and signs. But even if no definitive evidence of IFIs is provided,early antifungal therapy is mandatory for eligible patients. This review focuses on the clinical symptoms and signs and diagnostic modalities for IFIs in children,in order to provide clues and support for early diagnosis,improvement of disease outcome and reduction of disease burden of IFIS.