爆发抑制及其与麻醉药物关系

Burst suppression and its relationship with anesthetics

爆发抑制(burst suppression,BS)是大脑皮质电活动严重受抑制的表现,麻醉药物是常见的BS诱发因素。目前BS发生机制尚不清楚,各种药物单用及混用诱发BS的剂量是重要研究方向。文章旨在综述BS国内外研究现状,主要包括BS的定义和判断标准、各种药物与BS的关系、BS的预后。爆发抑制率(burst suppression ratio,BSR)可作为临床麻醉的常规监测指标,使麻醉医师更易调节麻醉深度。

Burst suppression(BS)is a sign of severe inhibition of electrical activity in the cerebral cortex.Anesthetic is a common reason of inducing BS.Hitherto,the mechanism underlying BS is unclear.The dose of anesthetic alone or in combination in ducing BS is an important research target.This review presents current research advances of BS home and abroad,including the relationship between anesthetics and BS,the definition,judgment criteria and prognosis of BS.In the future,burst suppression ra tio(BSR)can be used as a routine monitoring index for clinical anesthesia,making it easier for anesthesiologists to adjust the depth of anesthesia.