摘要
To the Editor:Esophageal cancer is the sixth most common cancer globally according to the World Health Organization.[1] Due to rapid clinical progression and extremely poor prognosis,the 5-year survival rate of esophageal squamous cell carcinomas(ESCC)remains less than 20%;[2]therefore,further developments in this field are needed.Human papillomavirus(HPV)is a small circular non-enveloped double-stranded DNA virus that primarily infects mucosa and cutaneous keratinocytes[3] and its infection rates in ESCC range from 11.7% to 38.9% worldwide.[4] P16 which is encoded by the CDKN2A gene and known as cyclin-dependent kinase inhibitor 2A,is a widely used immunohistochemical marker in squamous cell carcinomas and associated with high-risk HPV.[5]
基金
This work was supported by grants from the Henan Medical Science and Technology Project(general)(No.201401017)
the National Natural Science Foundation of China(No.81602637).
