高氯血症与危重患者肾功能障碍的相关性研究进展

Advances in research on the relationship between hyperchloremia and renal dysfunction in critically ill patients

氯离子(Cl^-)是一种具有重要生理作用的生物活性物质,对重症监护室(ICU)患者进行静脉液体输注治疗导致血浆Cl^-浓度异常是临床常见的现象.近年来,有关血浆Cl^-浓度升高造成的高氯血症对危重患者肾功能障碍影响的相关研究不断深入.本文简述了Cl^-的来源、分布和代谢等生理基础,回顾了国内外有关高氯血症与肾功能障碍发生的相关性研究进展,分析了Cl^-影响肾功能的潜在机制,为深入开展高氯血症对危重患者肾功能障碍影响的研究提供了理论基础.

Chloride ion(Cl^-)is a biologically,active electrolyte with important physiological effects.Intravenous fluid infusion therapy in patients in in tensive carr unit(ICU),resulting in abn ormal plasma chloride concentration is a common clinical symptom.In recent years,studies on the effects of hyperchloremia caused hy elevated plasma chloride concentrations on renal dysfunction in critically ill patients have continued.This paper briefly described the physiological basis of Cl^-,including its source,distribution and metabolism.It reviewed the research progress of the relationship between hyperchloremia and renal dysfunction al home and abroad,and analyzed llir potential mechanism of Cl^- affecting renal function,to establish an in-depth study cn the impact of hyperchloremia on the occurrence of renal dysfunction in critically ill patients.