沙丁醇胺、噻托溴铵联合乙酰半胱氨酸治疗慢阻肺急性加重期的临床效果

Clinical effect of salbutamol,tiotropium bromide and acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探讨沙丁醇胺、噻托溴铵联合乙酰半胱氨酸治疗慢阻肺急性加重期(AECOPD)的效果。方法将我院96例AECOPD患者按不同治疗方案分为对照组与观察组,各46例。对照组给予沙丁胺醇联合噻托溴铵治疗,观察组在此基础上给予乙酰半胱氨酸治疗。比较两组疗效。结果治疗后,两组FEV1/FVC、TLC均升高,T/D、WA、CysC、ICAM-1、MMP-2水平、SGRQ评分均降低,观察组低于对照组(P<0.05)。结论沙丁醇胺、噻托溴铵联合乙酰半胱氨酸治疗AECOPD效果显著,值得临床应用。

Objective To investigate the effect of salbutamol,tiotropium bromide and acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 92 patients with AECOPD were divided into control group and observation group by different treatment schemes,with 46 cases in each group.The control group was treated with salbutamol and tiotropium bromide,and the observation group was treated with acetylcysteine on this basis.The clinical treatment effects of the two groups were compared.Results After treatment,the FEV1/FVC,TLC of the two groups increased,and T/D,WA,levels of CysC,ICAM-1,MMP-2 and SGRQ scores decreased,and those in the observation group were better than the control group(P<0.05).Conclusion The salbutamol,tiotropium bromide combined with acetylcysteine in patients with AECOPD has significant effect,which is worthy of clinical application.