摘要
目的探讨甲状腺自身抗体阳性对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法选取我院收诊的72例行IVF-ET治疗的不孕妇女作为研究对象,按照血清甲状腺自身抗体检测结果分为观察组(36例,阳性)和对照组(36例,阴性)。比较两组的性激素水平和妊娠结局;分析甲状腺自身抗体阳性和妊娠率、优胚率、卵裂率、获卵数及IVF受精率的相关性。结果观察组的早期流产率高于对照组(P<0.05)。观察组和对照组的E2、LH、FSH水平及妊娠率、优胚率、卵裂率、获卵数、IVF受精率比较,差异均无统计学意义(P>0.05)。患者的TPO-Ab、TG-Ab和IVF受精率均呈负相关(P<0.05)。结论甲状腺自身抗体呈阳性会对行IVF-ET不孕妇女的妊娠结局产生不良影响,临床应进行有效预防及治疗。
Objective To explore the effect of thyroid autoantibodies positive on IVF-ET pregnancy outcomes.Methods A total of 72 infertile women who received IVF-ET treatment in our hospital were selected as the study objects.According to the test results of serum thyroid autoantibodies,the patients were divided into observation group(36 cases,positive)and control group(36 cases,negative).The sex hormones levels and pregnancy outcomes of the two groups were compared;the correlation between thyroid autoantibodies positive and pregnancy rate,excellent embryo rate,cleavage rate,number of oocytes obtained and IVF fertilization rate were analyzed.Results The early abortion rate of the observation group was higher than that of the control group(P<0.05).There were no significant differences in E2,LH,FSH levels,pregnancy rate,excellent embryo rate,cleavage rate,number of oocytes obtained and IVF fertilization rate between the observation group and control group(P>0.05).The correlation coefficient between TPO-Ab,TG-Ab and IVF fertilization rate in patients with positive thyroid autoantibodies were negatively correlated(P<0.05).Conclusion Positive thyroid autoantibodies will have adverse effects on pregnancy outcome of infertile women undergoing IVF-ET,which should be effectively prevented and treated clinically.
作者
褚宇强
CHU Yu-qiang(Reproductive Research Institute of Luoyang Women's and Children's Health Care Center,Luoyang 471000,China)
出处
《临床医学研究与实践》
2020年第11期88-89,共2页
Clinical Research and Practice
