肠道益生菌联合蒙脱石散治疗小儿过敏性腹泻的临床效果

Clinical effect of intestinal probiotics combined with montmorillonite powder in the treatment of allergic diarrhea in children

目的探讨肠道益生菌联合蒙脱石散治疗小儿过敏性腹泻的临床效果。方法将我院收治的116例过敏性腹泻患儿按照入院治疗先后顺序随机分为对照组和联合组,各58例。两组患儿入院后均给予对症治疗,对照组给予蒙脱石散,联合组给予蒙脱石散+双歧杆菌四联活菌片。比较两组患儿的治疗效果。结果联合组的治疗总有效率高于对照组(P<0.05)。联合组的止泻、止吐、退热、常规便检恢复正常及住院时间均短于对照组(P<0.05)。治疗后,两组的血清CRP、IL-6、TNF-α水平均降低,IL-4水平均升高,且联合组优于对照组(P<0.05)。结论肠道益生菌联合蒙脱石散治疗小儿过敏性腹泻能显著改善患儿的临床症状,抑制炎症反应,提高机体免疫力,且治疗安全性高。

Objective To explore the clinical effect of intestinal probiotics combined with montmorillonite powder in the treatment of allergic diarrhea in children.Methods A total of 116 children with allergic diarrhea admitted in our hospital were randomly divided into control group and combined group by the sequence of hospitalization treatment,with 58 cases in each group.Both groups were given symptomatic treatment after admission,the control group was given montmorillonite powder,the combined group was given montmorillonite powder+bifidobacterium quadruple viable tablet.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was higher than that in the control group(P<0.05).The stop diarrhea and vomiting,fever abatement,normal recovery of routine stool examination and hospitalization times in the combined group were shorter than those in the control group(P<0.05).After treatment,the levels of serum CRP,IL-6 and TNF-αin the two groups decreased,while the level of IL-4 increased,and those in the combined group were better than the control group(P<0.05).Conclusion Intestinal probiotics combined with montmorillonite powder in the treatment of children with allergic diarrhea can significantly improve the clinical symptoms of children,inhibit the inflammatory response,improve the immunity of body,and the treatment safety is high.