1例甲泼尼龙严重过敏反应引发的输液思考

Thinking of infusion caused by a case of allergic reaction of methylprednisolone

报道1例甲泼尼龙琥珀酸钠注射剂稀释液与头孢类抗生素溶液直接转接输液过程中发生严重双硫仑样反应的个案,探讨其对肝脏疾病患者临床输液的意义。详细记录该患者的临床输液抢救过程,回顾相关文献,分析关联性,获得结果。由此延伸到肝脏疾病患者输液中多烯磷脂酰胆碱注射液的安全使用。临床上甲泼尼龙发生药物过敏反应极属少见,多烯磷脂酰胆碱注射液的相关此类反应也未见报道,本研究对临床静脉安全输液具有指导意义。

A case of severe disulfiram-like reaction occurred during direct transfer infusion of methylprednisolone sodium succinate injection diluent and cephalosporin antibiotic solution was reported,and its significance for clinical infusion in patients with liver diseases was discussed.The clinical infusion rescue process of the patient was recorded in detail,the relevant literature was reviewed,the correlation was analyzed,and the results were obtained.This extends to the safe use of polyene phosphatidylcholine injection in infusion of patients with liver disease.The drug allergic reaction of methylprednisolone is very rare in clinic,and the related reactions of polyene phosphatidylcholine injection have not been reported,the study has guiding significance for clinical intravenous safe infusion.