孕激素辅助宫腔镜电切术治疗早期子宫内膜癌的临床效果及对患者生育功能的影响

Clinical effect of progesterone assisted hysteroscopic electrotomy in the treatment of early endometrial cancer and its influence on the reproductive function of patients

目的探讨孕激素辅助宫腔镜电切术治疗早期子宫内膜癌的临床效果及对患者生育功能的影响。方法选取2014年1月至2016年12月我院收治的60例早期子宫内膜癌患者为研究对象,根据随机数表法将其分为对照组与研究组,各30例。对照组给予常规宫腔镜电切术治疗,研究组给予孕激素辅助宫腔镜电切术治疗。比较两组的临床疗效、治疗前、后的体重、血清CA125水平、VAS评分、再次妊娠情况。结果治疗后,研究组的治疗总有效率高于对照组(P<0.05)。治疗前,两组的体重、血清CA125水平比较,差异无统计学意义(P>0.05);治疗后,研究组的体重轻于对照组,血清CA125水平低于对照组(P<0.05)。治疗前,两组的VAS评分比较,差异无统计学意义(P>0.05);治疗后,两组的VAS评分均降低,且研究组低于对照组(P<0.05)。研究组的治疗后1年内成功受孕率、足月生产率均高于对照组(P<0.05)。结论孕激素辅助宫腔镜电切术治疗早期子宫内膜癌的效果确切,而且可以有效提高患者的生育功能,值得临床推广应用。

Objective To investigate the clinical effect of progesterone assisted hysteroscopic electrotomy in the treatment of early endometrial cancer and its influence on the reproductive function of patients.Methods From January 2014 to December 2016,60 patients with early endometrial cancer admitted in our hospital were selected as the study objects,and the patients were divided into control group and study group according to the random number table method,with 30 cases in each group.The control group was treated with conventional hysteroscopic electrotomy,and the study group was treated with progesterone assisted hysteroscopic electrotomy.The clinical effects,body weight,serum CA125 level,VAS score before and after treatment and second pregnancy of the two groups were compared.Results After treatment,the total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Before treatment,there were no significant differences in body weight and serum CA125 level between the two groups(P>0.05);after treatment,the body weight in the study group was lighter than that in the control group,and the serum CA125 level was lower than that in the control group(P<0.05).Before treatment,there was no significant difference in the VAS score between the two groups(P>0.05);after treatment,the VAS score in the two groups decreased,and that in the study group was lower than the control group(P<0.05).The successful pregnancy rate during 1 year after treatment and full-term productivity rate in the study group were higher than those in the control group(P<0.05).Conclusion Progesterone assisted hysteroscopic electrotomy is effective in the treatment of early endometrial cancer,and it can effectively improve the reproductive function of patients,which is worthy of popularization and application.