吡格列酮联合前列地尔治疗糖尿病肾病的临床效果

Clinical effect of pioglitazone combined with alprostadil in the treatment ofdiabetic nephropathy

目的探讨吡格列酮联合前列地尔治疗糖尿病肾病(DN)的临床效果。方法选取我院收治的DN患者96例,随机分为对照组(48例,吡格列酮)和观察组(48例,吡格列酮+前列地尔)。比较两组的治疗效果。结果治疗后,两组的NGAL、Cys C、UAE、KIM-1、VEGF、vWF、ET-1水平均明显降低,且观察组明显低于对照组(P<0.05)。两组的不良反应总发生率无明显差异(P>0.05)。结论吡格列酮联合前列地尔治疗糖尿病肾病的临床效果显著,能够有效改善患者肾脏功能和血管内皮功能指标,且安全性高。

Objective To explore the clinical effect of pioglitazone combined with alprostadil in the treatment of diabetic nephropathy(DN).Methods A total of 96 patients with DN admitted in our hospital were randomly divided into control group(48 cases,pioglitazone)and observation group(48 cases,pioglitazone+prostaglandin).The therapeutic effects of the two groups were compared.Results After treatment,the levels of NGAL,Cys C,UAE,KIM-1,VEGF,vWF and ET-1 in both groups reduced significantly,and those in the the observation group were significantly lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Pioglitazone combined with alprostadil in the treatment of DN has a significant clinical effect,it can effectively improve the indexes of renal function and vascular endothelial function,and has high safety.