胃癌组织中RAP2B的表达与临床意义

Expression and clinical significance of RAP2B in gastric cancer

目的检测RAP2B基因在胃癌、慢性萎缩性胃炎及正常胃黏膜中的表达情况,深入探究RAP2B基因在胃癌发病中的可能机制及临床意义。方法将2017年1月至2018年12月兵器工业521医院收治的80例经病理证实的胃癌患者的胃癌组织设为胃癌组,将36例慢性萎缩性胃炎组织设为胃炎组,22例正常胃黏膜组织设为对照组。比较RAP2B在胃癌组织、慢性萎缩性胃炎及正常胃黏膜中的表达情况,并分析其在胃癌组织中表达水平的影响因素。结果胃癌组中RAP2B的阳性表达率为80.00%(64/80),高于胃炎组的58.33%(21/36),高于对照组的22.73%(5/22),差异具有统计学意义(P<0.05)。胃癌组中,不同性别、年龄、肿瘤大小、TNM分期患者的RAP2B表达情况比较,差异无统计学意义(P>0.05);不同分化程度患者的RAP2B表达情况比较,差异具有统计学意义(P<0.05);有淋巴转移患者的RAP2B阳性表达率高于无淋巴转移患者,差异具有统计学意义(P<0.05)。结论RAP2B基因阳性表达率在正常胃黏膜、慢性萎缩性胃炎、胃癌组织中逐步增高,RAP2B基因可能为促进胃癌发生的原癌基因。

Objective To detect the expression of RAP2B gene in gastric cancer,chronic atrophic gastritis and normal gastric mucosa,and to explore the possible mechanism and clinical significance of RAP2B gene in gastric cancer.Methods From January 2017 to December 2018,the gastric cancer tissue of 80 patients with gastric cancer confirmed by pathology admitted in 521 hospital of norinco group were set as gastric cancer group,36 cases of chronic atrophic gastritis tissues were set as gastritis group,and 22 cases of normal gastric mucosa tissues were set as control group.The expression of RAP2B in gastric cancer,chronic atrophic gastritis and normal gastric mucosa were compared,and the influencing factors of its expression levels in gastric cancer were analyzed.Results The positive expression rate of RAP2B in the gastric cancer group was 80.00%(64/80),which was higher than 58.33%(21/36)in the gastritis group and 22.73%(5/22)in the control group,the differences were statistically significant(P<0.05).In gastric cancer group,there were no significant differences in the expression of RAP2B in patients with different gender,age,tumor size and TNM stage(P>0.05).The expression of RAP2B in patients with different degrees of differentiation has statistically significan difference(P<0.05);the positive expression rate of RAP2B in patients with lymph node metastasis was higher than that in patients without lymph node metastasis,the difference was statistically significant(P<0.05).Conclusion The positive expression rate of RAP2B gene is gradually increased in normal gastric mucosa,chronic atrophic gastritis and gastric cancer tissue.RAP2B gene may be a proto oncogene promoting the development of gastric cancer.