微创旋切术联合乳癖散结胶囊治疗乳腺增生合并乳腺纤维瘤的临床效果

Clinical effect of minimally invasive rotation surgery combined with Rupi Sanjie capsule in the treatment of mammary gland hyperplasia with mammary gland fibroma

目的探讨微创旋切术联合乳癖散结胶囊治疗乳腺增生合并乳腺纤维瘤的临床效果。方法选择我院128例乳腺增生合并乳腺纤维瘤患者为研究对象,利用随机数字法将其分成观察组和对照组,各64例。对照组采用微创旋切术治疗,观察组在对照组基础上术后给予患者乳癖散结胶囊进行治疗。比较两组患者的临床疗效、治疗前、后的雌酮(E1)、雌二醇(E2)、雌三醇(E3)、孕酮(PT)和泌乳素(PRL)、基质金属蛋白酶-9(MMP-9)、可溶性E-钙粘蛋白(sE-cadherin)水平、雌激素受体(ER)和孕激素受体(PR)的表达含量、复发情况及并发症总发生率,并分析观察组的用药安全性。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组的E1、E2、E3、PT及PRL水平均降低,且观察组E1、E2、E3及PT水平均低于对照组(P<0.05);治疗后,两组的PRL水平无显著差异(P>0.05)。治疗后,观察组的MMP-9、sE-cadherin水平及ER、PR含量均显著低于治疗前及对照组,差异具有统计学意义(P<0.05)。两组治疗后1年的复发率无显著差异(P>0.05)。观察组用药期间出现头晕2例,恶心呕吐1例,肢体乏力2例,均为轻微不良反应,患者自行缓解。结论微创旋切术联合乳癖散结胶囊治疗乳腺增生合并乳腺纤维瘤患者,可提高疗效,降低雌性激素分泌和复发风险,治疗安全性较高。

Objective To explore the clinical effect of minimally invasive rotation surgery combined with Rupi Sanjie capsule in the treatment of mammary gland hyperplasia with mammary gland fibroma.Methods A total of 128 patients with mammary gland hyperplasia and mammary gland fibroma in our hospital were selected as the study objects.The patients were divided into observation group and control group by random number method,with 64 cases in each group.The control group was treated with minimally invasive rotation surgery,while the observation group was treated with Rupi Sanjie capsule after surgery on the basis of the control group.The clinical efficacy,the levels of estrone(E1),estradiol(E2),estriol(E3),progesterone(PT)and prolactin(PRL),matrix metalloproteinase-9(MMP-9),soluble E-cadherin(sE-cadherin),the expression contents of estrogen receptor(ER),progesterone receptor(PR)before and after treatment,recurrence and the total incidence of complications were compared between the two groups,and the safety of medication in the observation group were analyzed.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of E1,E2,E3,PT and PRL in the two groups decreased,and the levels of E1,E2,E3 and PT in the observation group were significantly lower than those in the control group(P<0.05);after treatment,there was no significant difference in PRL level between the two groups(P>0.05).After treatment,the levels of MMP-9,sE-cadherin,the contents of ER and PR in the observation group were significantly lower than those before treatment and in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the recurrence rate at one year after treatment between the two groups(P>0.05).During medication in the observation group,there were 2 cases of dizziness,1 case of nausea and vomiting,and 2 cases of limb weakness,all of them were mild adverse reactions,and the patients resolved spontaneously.Conclusion Minimally invasive rotation surgery combined with Rupi Sanjie capsule in the treatment of patients with mammary gland hyperplasia and mammary gland fibroma can improve the efficacy,reduce estrogen secretion and the risk of recurrence,and has high safety.