维生素A缺乏对免疫细胞的影响及其在哮喘中作用的研究进展

Advances in effects of vitamin A deficiency on immune cells and their role in asthma

维生素A和其代谢产物视黄酸(RA)对免疫系统发挥其生理和病理功能有着全方面的影响。哮喘是由于Th1细胞和ILC1s功能相对抑制,Th2细胞和ILC2s功能相对亢进,使Th2细胞的数量及其分泌的Ⅱ类细胞因子增多,IgE大量合成,最终导致哮喘气道改变。当维生素A缺乏时,会导致Ⅱ类细胞因子增多,但是其具体的作用机理还不太清楚,本文就维生素A缺乏对哮喘的影响及机制研究进展作一综述。

Vitamin A and its metabolite,retinoic acid(RA),have a full impact on the immune system′s physiological and pathological functions.Asthma is due to the relative inhibition of Th1 cells and ILC1s function.The function of Th2 cells and ILC2s is relatively hyperactive,which increases the number of Th2 cells and the secretion of classⅡcytokines.IgE is synthesized in large quantities,which eventually leads to airway changes in asthma.When vitamin A is deficient,it will lead to an increase in typeⅡcytokines,but its specific mechanism of action is still not clear.This article reviews the progress of vitamin A deficiency on asthma and its research progress.