水盐代谢相关激素在梅尼埃病发病中作用的研究

Research on Roles of Hormones RegulatingWater-salt Metabolism in Pathogenesis of Meniere's Disease

梅尼埃病(meniere's disease,MD)是一种特发性内耳疾病,其特征性临床表现为发作性眩晕、波动性听力下降、耳鸣和(或)耳闷胀感。目前认为其病理基础为特发性膜迷路积水,但膜迷路积水机制尚不明了。主要病因学假说包括:内淋巴吸收障碍、内淋巴生成过多、内分泌紊乱、免疫反应、自主神经功能紊乱、病灶及病毒感染等。近年来有学者关注到人体内水盐代谢相关激素与MD的发生可能有关,本文就调节水盐代谢的几种激素在MD发病中可能的机制进行综述,包括抗利尿激素和肾上腺皮质激素。

Meniere's disease(MD)is an idiopathic inner-ear disease,whose remarkable clinical features include episodic vertigo,transient hearing loss,tinnitus and/or aural fullness.Membranous labyrinth hydrops is the main pathological finding,but its mechanism is still unknown.Main etiological hypotheses include obstruction of endolymph absortion,excessive endolymphatic production,endocrine disorders,immune responses,autonomic nervous system dysfunction and virus infection.Some scholars have recently concentrated on the relations between MD and hormones that regulate water-salt metabolism.In this artical we will review several hormones involved in regulating water-salt metabolism and possibly in the pathogenesis of MD,such as antidiuretic hormones and adrenocortical hormones.