巨噬细胞在新生隐球菌感染过程中的作用及机制概述

The role and mechanism of macrophages in the progress of Cryptococcus neoformans infection

新生隐球菌(Cryptococcus neoformans,C.neoformans)是一种酵母样真菌,既可引起肺组织感染,也可引起危及生命的脑膜脑炎。当新生隐球菌感染人体后,巨噬细胞作为第一道免疫防线,迅速识别、吞噬及破坏病原体。新生隐球菌与巨噬细胞相互作用的不同结果会导致疾病向不同的结局发展,了解这些作用机制对于隐球菌病的防治起到关键作用。本文就新生隐球菌感染期间与巨噬细胞的相互作用及内在分子机制作一综述,以期为疫苗研制及免疫疗法提供理论基础和方向。

Cryptococcus neoformans(C. neoformans) is a yeast-like fungus, which can not only cause lung tissue infection, but also cause life-threatening meningoencephalitis. When humans are infected with C. neoformans, macrophages act as the first line of immune defense to quickly identify, phagocytose and destroy pathogens. The diffe-rent results of interactions between C. neoformans and macrophages will lead to different outcomes, understanding these mechanisms plays a key role in the prevention and treatment of cryptococcosis. This article reviews the intera-ction between C. neoformans and macrophages and the intrinsic molecular mechanism during infection, and provides theoretical basis and direction for vaccine development and immunotherapy of cryptococcosis.