MicroRNAs在酒精性脂肪肝形成机制中的作用研究进展

Advances on the role of mi RNAs in the formation of alcoholic fatty liver

酒精性脂肪肝(AFLD)是指长期大量饮酒引起的以肝脏脂肪变性为主的病理变化,其形成机制主要包括脂质代谢异常、免疫炎性反应、肠道菌群失调及乙醇代谢酶紊乱等。近年来,大量研究证实微小RNA(miRNAs)在多种疾病的诊疗中发挥着重要作用,miRNAs参与AFLD形成的分子调控机制研究也成了热点。许多研究通过探讨miRNAs与AFLD形成途径中关键基因的靶向作用关系,建立其与该信号通路下游基因的促进或抑制表达网络,以揭示miRNAs在AFLD形成机制中的作用。该文综述了AFLD形成通路中重要的miRNAs及其在AFLD中的调控机制,旨在为深入理解miRNAs功能及其在AFLD中的相关作用机制提供理论依据。

Alcoholic fatty liver disease(AFLD)is a pathological change of liver steatosis caused by long-term heavy alcohol consumption.The mechanism of AFLD formation mainly includes abnormal lipid metabolism,immune-inflammatory reaction,intestinal flora imbalance,alcohol metabolism enzyme disorder and so on.In recent years,numerous studies have confirmed that micro RNA(mi RNA)plays an important role in diagnosis and treatment of many diseases,the molecular regulatory mechanism of miRNAs involved in AFLD formation has also become a research focus.The majority of studies have explored the role of miRNAs in AFLD formation by exploring the targeting role of miRNAs of key genes in the formation pathway of AFLD,and establishing an expression network with genes that promote or inhibit the expression of downstream genes of this signaling pathway.In present paper,the important miRNAs in the formation pathway of AFLD and their regulatory mechanisms in AFLD are reviewed,so as to provide theoretical basis for further understanding the function of miRNAs and its relevant mechanisms in AFLD.