MRI显微线圈成像与类风湿关节炎抗CCP抗体及RF水平的关系

Correlation between MRI microcoil and anti-CCP antibody and RF level in rheumatoid arthritis

目的探究MRI显微线圈半定量与类风湿关节炎(RA)抗环化瓜氨酸多肽(CCP)抗体及类风湿因子(RF)水平的关系。方法选取2018年6月至2020年1月我院收治的80例RA患者作为研究对象。对所有患者行MRI显微线圈平扫和增强扫描,应用半定量法对滑膜评分分级,同时收集患者血清RF和抗CCP抗体水平,分析滑膜评分与血清因子的相关性。结果X线平片阳性有15例,阳性率为18.75%。而MRI显微线圈图像显示有一定程度的RA症状阳性率为100%,MRI显微线圈的阳性率明显高于X线(χ2=109.474,P=0.000);80例早期RA患者表现为不同程度的滑膜增厚症状;骨质侵蚀组血清RF和抗CCP抗体水平明显高于骨质正常组(P<0.05);滑膜总评分分别与血清RF(r=0.561,P=0.000)和抗CCP抗体(r=0.631,P=0.000)呈正相关。结论MRI显微线圈半定量法可有效评估早期RA滑膜炎情况,且滑膜评分与血清RF和抗CCP抗体呈正相关,对早期诊断RA有一定价值。

Objective To investigate the correlation between semi-quantitative MRI microcoil and anti-CCP antibody and rheumatoid factor(RF)level in rheumatoid arthritis(RA).Methods A total of 80 RA patients treated in our hospital from June 2018 to March 2019 were enrolled.MRI microcoil plain scan and enhanced scan were performed on all patients.Synovial score was graded by semi-quantitative method.Serum RF and anti-CCP antibody levels were collected to analyze the correlation between synovial score and serum factors.Results Totally 15 cases were tested positive by X-ray plain film,with a positive rate of 18.75%,while the positive rate of MRI microcoil image was 100%.The positive rate of MRI microcoil was significantly higher than that of X-ray(χ2=109.474,P=0.000);80 patients with early RA showed different degrees of synovial thickening;the levels of serum RF and anti-CCP antibody of RA patients in bone erosion group were significantly higher than those of RA patients in normal bone group(P<0.05);the total score of synovium was positively correlated with serum RF(r=0.561,P=0.000)and anti-CCP antibody(r=0.631,P=0.000).Conclusion MRI microcoil semi-quantitative method can effectively evaluate the situation of early RA synovitis,and the synovial score is positively correlated with serum RF and anti-CCP antibody,which has a certain value for early diagnosis of RA.