噻托溴铵联合福莫特罗吸入治疗慢性阻塞性肺疾病的临床效果

Clinical effect of Tiotropium Bromide combined with Formoterol inhalation in the treatment of chronic obstructive pulmonary disease

目的探讨噻托溴铵联合福莫特罗吸入治疗慢性阻塞性肺疾病的临床效果。方法选取2017年2月~2019年2月我院收治的60例慢性阻塞性肺疾病患者作为研究对象,按照随机数字表法将其分为对照组(30例)与观察组(30例)。对照组患者单用噻托溴铵治疗,观察组患者给予噻托溴铵联合福莫特罗吸入治疗。观察两组患者的临床疗效及不良反应发生情况,并比较两组患者治疗前后的肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1占FVC的比例(FEV1/FVC)]、每分钟最大通气量(MVV)、呼吸困难量表(MRC)评分及6 min步行距离(6MWD)。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的FEV1、FVC、FEV1/FVC、MVV均高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的MRC评分低于对照组,6MWD远于对照组,差异有统计学意义(P<0.05)。两组治疗期间未发生严重的不良反应。结论慢性阻塞性肺疾病患者给予噻托溴铵联合福莫特罗吸入治疗效果显著,可提高肺功能,改善患者呼吸困难症状,增加运动耐力,促进病情的转归,且联合用药具有一定安全性。

Objective To investigate the clinical effect of Tiotropium Bromide combined with Formoterol inhalation in the treatment of chronic obstructive pulmonary disease.Methods Sixty patients with chronic obstructive pulmonary disease admitted to our hospital from February 2017 to February 2019 were selected as the research subjects,and they were divided into the control group(30 cases)and the observation group(30 cases)according to the random number table method.Patients in the control group were treated with Tiotropium Bromide alone,and patients in the observation group were given Tiotropium Bromide combined with Formoterol inhalation.The clinical efficacy and incidence of adverse reactions of the two groups of patients were observed,and the lung function(forced expiratory volume in one second[FEV1],forced vital capacity[FVC],FEV1 to FVC ratio[FEV1/FVC]),maximal voluntary ventilation(MVV),dyspnea scale(MRC)score and 6 min walking distance(6MWD)before and after treatment were compared between the two groups of patients.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The FEV1,FVC,FEV1/FVC,and MVV after treatment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The MRC score of patients in the observation group was lower than that in the control group,the 6MWD was farther than that in the control group,and the differences were statistically significant(P<0.05).No serious adverse reactions occurred during the treatment of the two groups.Conclusion Tiotropium Bromide combined with Formoterol inhalation in the treatment of patients with chronic obstructive pulmonary disease has significant effect,it can increase pulmonary function,improve dyspnea,enhance exercise tolerance,and promote outcome of the disease,which has certain safety.