重复经颅磁刺激在精神分裂症长期住院患者中的应用

Application of repeated transcranial magnetic stimulation in long-term hospitalized patients with schizophrenia

目的探讨重复经颅磁刺激(rTMS)在精神分裂症长期住院患者中的临床效果。方法选取2017年2~8月我院精神科收治的50例精神分裂症患者为研究对象,按患者就诊先后顺序分为试验组和对照组,每组25例。对照组患者给予假刺激,试验组患者给予rTMS。比较两组患者治疗前、治疗4周、治疗8周和随诊6个月的阳性与阴性症状量表(PANSS);比较两组患者治疗前后的精神护理观察量表(NORS)和个人与社会表现量表(PSP)。结果试验组治疗4、8周和随诊6个月的阳性症状、一般精神评分低于对照组,试验组治疗8周和随诊6个月的PANSS总分低于对照组,差异均有统计学意义(P<0.05);试验组治疗后的生活自理能力评分高于对照组,治疗4、8周和随诊6个月的PSP评分高于对照组,文体活动、环境适应、精神症状评分及总分低于对照组,差异均有统计学意义(P<0.05)。结论rTMS对精神分裂症长期住院患者社会功能及生活质量有积极作用,能有效提高患者的社会功能和生活质量。

Objective To explore the clinical effect of repeated transcranial magnetic stimulation(rTMS)in long-term hospitalized patients with schizophrenia.Methods Fifty patients with schizophrenia treated in the department of psychiatry in our hospital from February to August 2017 were selected as the research subjects,and were divided into experimental group(n=25)and control group(n=25)according to the order of patient visits.Patients in the control group were given sham stimulation,and patients in the experimental group were provided with rTMS.The scores of the positive and negative symptoms scale(PANSS)before and after 4-and 8-week treatments and 6-month follow-up were compared.The mental nursing observation rating scale(NORS)scores and personal and social performance scale(PSP)before and after treatment were compared.Results The positive symptoms and general mental scores of the experimental group at 4-and 8-week treatments and 6-month follow-up were lower than those of the control group,the total scores of PANSS after 8-week treatment and 6-month follow-up in the experimental group were lower than those of the control group(P<0.05).The self-care ability score of the experimental group after treatment was higher than that of the control group,and the PSP scores at 4-and 8-week treatment and 6-month follow-up were higher than those of the control group,the scores of recreational activity,environmental adaptation and mental symptoms,and total score were lower than those in the control group(P<0.05).Conclusion rTMS has a positive effect on the social function and quality of life in long-term hospitalized patients with schizophrenia,and can effectively improve the social function and quality of life.