标准四联疗法及抗生素序贯疗法治疗幽门螺杆菌阳性胃溃疡的效果比较

Comparison of effects of standard quadruple therapy and antibiotic sequential therapy in treatment of Helicobacter pylori-positive gastric ulcer

目的:比较标准四联疗法及抗生素序贯疗法治疗幽门螺杆菌(Hp)阳性胃溃疡的效果。方法:选取80例Hp阳性胃溃疡患者为研究对象,按随机数字表法分为对照组与研究组各40例,对照组给予标准四联疗法,研究组给予抗生素序贯疗法,比较两组临床疗效、Hp根除率、复发率、治疗前后症状评分及不良反应发生率。结果:研究组治疗总有效率及Hp根除率明显高于对照组,复发率明显低于对照组,差异均有统计学意义(P<0.05);治疗后,两组症状评分均明显降低,且研究组明显低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:抗生素序贯疗法治疗Hp阳性胃溃疡患者可提高治疗总有效率和Hp根除率,降低复发率和症状评分,效果优于标准四联疗法治疗效果。

Objective: To compare effects of standard quadruple therapy and antibiotic sequential therapy in treatment of Helicobacter pylori(Hp)-positive gastric ulcer. Methods: 80 patients with Hp-positive gastric ulcer were selected as the research objects, and were divided into control group and study group by using the random number table method, 40 cases in each. The control group was given the standard quadruple therapy, while the study group used the sequential therapy. Then, the clinical efficacy, Hp eradication rate, recurrence rate, symptom scores before and after the treatment and incidence of adverse reactions were compared between the two groups. Results: The total effective rate and Hp eradication rate of the study group were significantly higher than those of the control group, the recurrence rate was significantly lower than that of the control group, and the differences were statistically significant(P<0.05). After the treatment, the symptom scores of the two groups were significantly reduced;those of the study group were significantly lower than those of the control group;and the differences were statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: For the patients with Hp-positive gastric ulcer, the antibiotic sequential therapy can improve the total effective rate and Hp eradication rate and reduce the recurrence rate and symptom score. Moreover, it is superior to the standard quadruple therapy.