阿昔洛韦不同用药方式治疗单纯疱疹病毒性角膜炎的疗效

Efficacy and safety of different antiviral medications in patients with herpes simplex keratitis

目的:比较阿昔洛韦不同用药方式治疗单纯疱疹病毒性角膜炎(HSK)的疗效。方法:回顾性分析2015年1月至2019年1月期间124例HSK患者的临床资料,根据治疗方式的不同分为对照组(61例)和观察组(63例)。对照组采用阿昔洛韦局部治疗,观察组行阿昔洛韦局部联合静脉注射治疗,比较两组患者的治疗效果以及安全性。结果:观察组痊愈率和有效率均高于对照组,差异有统计学意义(P<0.05);观察组起效时间、溃疡愈合时间、充血消退时间及刺激消失时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿昔洛韦局部联合静脉用药治疗HSK,能有效抑制病毒的增殖,且不增加不良反应,其效果优于单纯局部治疗。

Objective: To explore efficacy and safety of different antiviral medications in patients with herpes simplex keratitis(HSK). Methods: The clinical data of 124 HSK patients from January 2015 to January 2019 were retrospectively analyzed. According to the different treatment methods, they were divided into control group(61 cases) and observation group(63 cases). The control group received local antiviral Acyclovir alone, while the observation group received local antiviral Acyclovir combined with intravenous injection. The treatment effects and safety were compared between the two groups. Results: The curative rate and effective rate of the observation group were higher than those of the control group, and the differences were statistically significant(P<0.05). The onset time, ulcer healing time, hyperemia regression time and irritation disappearance time of the observation group were shorter than those of the control group, and the differences were statistically significant(P<0.05). Further, the incidence of adverse reactions in the observation group was 31.75%, which was significantly higher than 16.39% in the control group, and the difference was statistically significant(P<0.05). Conclusions: Single local antiviral Acyclovir therapy combined with intravenous application can effectively inhibit the proliferation of the virus. Moreover, it is superior to single local antiviral therapy.