西酞普兰治疗首发抑郁症老年患者对其临床症状及神经营养因子表达的影响

Effects of Citalopram on clinical symptoms and neurotrophic factor expression in elderly patients with first-episode depression

目的:观察西酞普兰治疗首发抑郁症老年患者对其临床症状及神经营养因子表达的影响。方法:选取收治的首发抑郁症老年患者66例,按随机数字表法分为对照组和观察组,每组33例。对照组予盐酸氟西汀治疗,观察组予草酸艾司西酞普兰治疗。治疗前后采用汉密尔顿抑郁量表17项(HAMD-17)评估两组患者抑郁症状程度,采取免疫吸附法检测并比较两组神经营养因子表达水平及不良反应发生率。结果:治疗后2、4、6个月,两组HAMD-17评分均较治疗前明显降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后6个月,两组血清神经生长因子、脑源性神经营养因子、神经营养素-3表达水平均较治疗前提升,且观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率为24.24%,低于对照组的48.48%,差异有统计学意义(P<0.05)。结论:西酞普兰治疗首发抑郁症老年患者可改善临床症状和提高神经营养因子表达水平的效果优于盐酸氟西汀治疗效果。

Objective: To observe effects of Citalopram on clinical symptoms and neurotrophic factor expression in elderly patients with first-episode depression. Methods: Sixty-six elderly patients with first-episode depression were selected and divided into control group and observation group according to the random number table method, with 33 cases in each group. The control group was treated with Fluoxetine hydrochloride, while the observation group was treated with Escitalopram oxalate. Before and after treatment, the Hamilton depression scale 17(HAMD-17) was used to assess the degree of depression symptoms in the two groups. Then, the immunosorbent assay was used to detect and compare the expression levels of neurotrophic factors. Further, the incidence of adverse reactions in the two groups were compared. Results: Two, four and six months after the treatment, the HAMD-17 scores of the two groups were significantly lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05). Six months after the treatment, the expression levels of serum nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the observation group was 24.24%, which was lower than 48.48% in the control group, and the difference was statistically significant(P<0.05). Conclusions: Citalopram can improve the clinical symptoms and the neurotrophic factor expression levels in the elderly patients with first-episode depression. Moreover, it is superior to Fluoxetine hydrochloride.